In 1934, pathologist Harry Goldblatt established the first animal model of hypertension. This model provided researchers with the tools to delineate the renin-angiotensin system of blood pressure control and, eventually, to design enzyme inhibitors for the treatment of chronic hypertension.
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Robert Tigerstedt and the Discovery of Renin.
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From the Department of the History of Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland.
The year 2022 marks the 125th anniversary of the discovery of the first element of the renin-angiotensin-aldosterone system. The importance of this event on the further development of nephrology, cardiology, and endocrinology left us compelled to reminisce about it and its main author, Robert Tigerstedt (1853-1923), who was one of Scandinavia's most famous scientists. He studied medicine at the University of Helsinki, Finland.
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Center for the Arts and Humanities in Medicine and Program in the History of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address:
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