Background: The routine use of mitomycin C to enhance glaucomatous filtering surgery has found wide acceptance. Complications of the application of mitomycin C have been repeatedly noticed. We now report a previously undescribed complication showing a toxic effect of mitomycin C to the corneal endothelium.
Methods: Patients underwent routine trabeculectomy with mitomycin C. Following surgery, the eyes were examined by biomicroscopy and specular microscopy of the corneal endothelium.
Results: In two cases, we observed a partial decompensation of the corneal endothelium resulting in a well-demarcated clear zone of the cornea and a second zone with thickening of the cornea and a bullous keratopathy adjacent to the filtering bleb. The specular microscopy showed marked irregularities of the endothelial cells and areas of necrosis in those parts of the cornea close to the filtering bleb.
Conclusions: The two cases described here demonstrate that if the corneal endothelium is already compromised before surgery, the application of mitomycin C may have an additional toxic effect on the endothelium and may result in a partial bullous keratopathy. Surgeons should be aware of this complication.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00417-005-1170-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Current and emerging strategies for the manufacture, implantation, and clinical management of corneal tissue allografts.
Clin Exp Optom
December 2024
Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.
Article Synopsis
- Over the past 40 years, around 40,000 Australians have undergone corneal transplants, primarily due to conditions like keratoconus and Fuchs' dystrophy, with increasing demand due to an aging population.
- The global shortage of donor corneas is significant, with demand exceeding supply by 70 times, particularly in less-developed countries, prompting advancements in tissue banking and surgical techniques.
- New strategies like organ culture for donor corneas, bespoke surgical methods, and cell culture technologies are improving tissue storage, reducing transplant requirements, and enhancing patient care for corneal conditions.
Ripasudil's paradox: bullous keratopathy with honeycomb twist.
BMJ Case Rep
December 2024
Ophthalmology, All India Institute of Medical Sciences, Nagpur, India.
We present a case of a male patient in his mid-50s who presented with bullous keratopathy secondary to an anterior chamber intraocular lens, complicated by superimposed honeycomb keratopathy while on ripasudil 0.4%. The bullous keratopathy was characterised by generalised microcystic epithelial oedema, alongside more centrally located, variable-sized macrocystic epithelial oedema with a honeycomb appearance.
View Article and Find Full Text PDFFive Year Review of All Examined Corneal Tissue in a Tertiary Eye Care Center: Demographics and Surgical Indications.
J Epidemiol Glob Health
December 2024
Ophthalmology Department, King Saud University, Riyadh, Saudi Arabia.
Background: Corneal pathologies are among the most common reversible sight-threatening diseases globally. As such, corneal tissue transplantation (keratoplasty) techniques are evolving over time depending on the prevalence of different pathologies in each geographical area. We aim to provide a baseline information on the common keratoplasty procedures performed in our area in relation to prevalent corneal pathologies and to analyze common corneal surgical practice trends in our area.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to showcase cases of extreme corneal flattening, termed collagen compaction syndrome, following successful endothelial keratoplasty (EK).
- Four patients, averaging 64.8 years old, experienced significant vision problems after EK due to chronic corneal edema, with best-corrected vision ranging from 20/40 to 20/200.
- The findings suggest that the duration of chronic corneal edema before surgery may greatly impact EK outcomes, indicating the need for careful timing of the procedure and potential rescue treatments for patients with severe edema.
Graft detachment rates in surgeon-cut and pre-cut tissue for DSAEK transported in different mediums.
Acta Ophthalmol
November 2024
Department of Ophthalmology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.
Purpose: To analyse graft detachment rates after Descemet stripping automated endothelial keratoplasty (DSAEK) using surgeon-cut grafts and pre-cut grafts transported in different mediums.
Methods: A retrospective study of graft detachment rates including 265 surgeries (240 patients) performed between 2019 and 2023. The DSAEK grafts were either surgeon-cut (n = 135) or pre-cut and transported in a dextran-containing medium (n = 82) or in a dextran-free medium (n = 48).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!