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Central nervous system (CNS) involvement by lymphoproliferative disorders is rare and associated with a poor prognosis. CNS involvement can be exclusive, primary or appear in a secondary manner as part of a systemic process. The spectrum of involvement that we encounter is varied and neuroimaging plays a key role in diagnosis.

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Primary central nervous system lymphoma (PCNSL) represents 5% of malignant primary brain tumors. The clinical presentation typically includes focal neurological symptoms, increased intracranial pressure, seizures, and psychiatric symptoms. Although histological examination remains the gold standard for diagnostic confirmation, non-invasive imaging plays a crucial role for the diagnosis.

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MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs.

Vet Radiol Ultrasound

March 2023

Diagnostic Imaging Department (Mattei, Specchi) and Neurology Department (Biserni), Ospedale Veterinario "I Portoni Rossi", Anicura Italy, Zola Predosa, Italy.

Article Synopsis
  • A study analyzed MRI images and histopathology from 12 dogs with confirmed IVL, revealing specific brain and spinal cord lesions characterized by hyperintensities and changes indicative of vascular issues.
  • The findings linked MRI features, like susceptibility artifacts and areas of infarction, to the unique blood vessel-targeting nature of IVL, highlighting ischemic and hemorrhagic influences caused by neoplastic infiltration in the affected areas.
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PET findings in lymphomatosis and gliomatosis of the brain: a comparison of C-11 methionine PET/CT and F-18 FDG PET/CT.

Acta Radiol

October 2021

Department of Neurosurgery, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama City, Fukushima, Japan.

Background: Positron emission tomography (PET) findings for gliomatosis and lymphomatosis have been rarely reported.

Purpose: To compare PET/computed tomography (CT) findings using C-methionine (MET) from PET/CT findings using F-fluorodeoxy glucose (FDG) for patients with lymphomatosis or gliomatosis of the brain.

Material And Methods: Participants comprised all 10 patients with lymphomatosis or gliomatosis of the brain treated at our institution in the past 12 years.

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Intravascular lymphomatosis (IVL) is a rare type of B-cell non-Hodgkin lymphoma (BCNHL), which can mimic many other diseases. Fever, neurological symptoms, and skin findings are the most frequent clinical findings. Intravascular lymphomatosis may be associated with genetic factors and infection with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV-8), human T-lymphotropic virus 1 (HTLV1), Epstein-Barr virus (EBV), and hepatitis B virus (HBV).

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