A histological examination of the pulmonary and bronchopulmonary lymph nodes was made in 47 patients treated surgically for fibrocavernous pulmonary tuberculosis. The speed of immunopathological reactions development is the main reason of differences between drug-resistant and drug-sensitive primary tuberculosis. Formation of cellular immunity in drug-resistant tuberculosis has all necessary morphological prerequisites both in the lungs and lymph nodes but their realization is delayed. Immunogenesis concentrates on the early stages when initial paraspecific reactions prevail. Morphologically, they are most demonstrative in the bronchial walls where in different patients or even in one patient but in various bronchi all reactions of delayed type (contact, tuberculine type and granulematous) can be simultaneously observed.
Download full-text PDF |
Source |
---|
Virusdisease
June 2024
Department of Phthisiology and Veneral Disease, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev Str., 030019 Aktobe, Republic of Kazakhstan.
The study aimed to ascertain the prevalence and frequency of relapses of respiratory tuberculosis (TB) and examine the characteristics of its clinical progression in members of the Kazakh population based on the alleles of the HLA-DRB1 gene. Methods of clinical and genetic research, statistical processing and analysis of the obtained data were used to achieve this goal. The research led to an analysis of the statistical processing of clinical and genetic investigations that found out how often TB in the respiratory tract is found and how different HLA-DRB1 gene alleles affect the disease's progression.
View Article and Find Full Text PDFPathophysiology
November 2019
Department of General and Clinical Pathophysiology, Medical Academy named after S.I. Georgievskiy of the V.I. Vernadsky Crimean Federal University, Republic of Crimea, Russian Federation.
Introduction: Tuberculosis (TB) remains one of the most dangerous infections with the high mortality in the whole world. The leading problems in the modern course of TB are both long-term therapy and appearance of multiplying and wide resistant forms, as well as the rise of comorbid pathology (e.g.
View Article and Find Full Text PDFThe clinical observation of the successful treatment of newly diagnosed fibro-cavernous pulmonary tuberculosis caused by mycobacteria of multidrug-resistant tuberculosis and the results of control of the effectiveness of treatment with modern high-tech radiation methods are presented. The necessity of an individual approach to the treatment of tuberculosis in this category of patients is shown.
View Article and Find Full Text PDFPatol Fiziol Eksp Ter
January 2018
Unlabelled: The purpose - comprehensive study of the purine metabolic enzymes in serum and immune cells in patients with pulmonary tuberculosis for the understanding of the pathogenesis of a specific lung disease.
Methods: The enzymes of purine metabolism (adenosine deaminase (ADA) and its isoenzymes (ADA-1 and ADA-2), dipeptidylpeptidase IV (DPPIV - CD26), ecto-5’-nucleotidase (5’-NC) in the blood and immune cells was studied in 29 and 76 patients with fibro-cavernous (FCPT) and infiltrative (IPT) pulmonary tuberculosis correspondingly.
Results: In patients found changes in purine metabolism, the severity and pathophysiological significance of which depend of clinical forms of tuberculosis, that is, from the gravity specific of the process.
The pulmonary tuberculosis process as dependent on the disease form and the therapy efficacy with the use of Cycloferon in the treatment scheme were investigated. The study had two stages. At the first stage the data concerning 358 patients with primary pulmonary tuberculosis and infiltration (93 patients) or degradation (89 patients) and 176 patients with pulmonary fibrocavernous tuberculosis were analysed.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!