Linkage disequilibrium is the association between alleles in the allele distributions across linked loci and is intermediate in character between the dependence and the independence of allele distribution. This ambivalence makes linkage disequilibrium difficult to understand and to treat mathematically. To overcome this difficulty, an attempt was made to divide linkage disequilibrium between absolute linkage disequilibrium, which is a complete dependence of allele distribution, and linkage equilibrium, which is a complete independence. A matrix description of linkage disequilibrium showed that (1) linkage disequilibrium is divided between absolute linkage disequilibrium and linkage equilibrium, (2) a linkage disequilibrium state is characterized by the allele frequency in the first locus p, the relative content of absolute linkage disequilibrium d and the linkage equilibrium variable c, and (3) r is the geometric mean of both orientation's d. Division of linkage disequilibrium may make linkage disequilibrium straightforward to understand and to treat mathematically.
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http://dx.doi.org/10.1007/s10038-005-0256-6 | DOI Listing |
Hum Immunol
January 2025
The Second Affiliated Hospital of Guangxi Medical University, Department of Nephrology, Nanning, Guangxi 530021, China. Electronic address:
Background: Microscopic polyangiitis (MPA) is a severe multisystem autoimmune disease featured by small-vessel vasculitis with few or no immune complex, also has a significant genetic predisposition. Growing evidence has confirmed that STAT4 gene is tightly associated with multiple autoimmune diseases, but its contribution to MPA onset is still elusive.
Objective: The aim was to investigated the association between STAT4 gene polymorphisms (rs7572482, rs7574865 and rs12991409) and MPA susceptibility in a Guangxi population of China.
Biology (Basel)
January 2025
Sanya Research Institute, Nanjing Agricultural University, Sanya 572025, China.
Understanding the genetic characteristics of indigenous goat breeds is vital for their conservation and breeding. Haimen goats, native to China's Yangtze River Delta, possess distinctive traits such as white hair, moderate growth rate, high-quality meat, and small body size. However, knowledge regarding the genetic structure and germplasm characteristics of Haimen goats remains limited.
View Article and Find Full Text PDFEvol Appl
January 2025
Save Our Seas Foundation Shark Research Center, Halmos College of Arts & Sciences Nova Southeastern University Dania Florida USA.
Large-bodied pelagic sharks are key regulators of oceanic ecosystem stability, but highly impacted by severe overfishing. One such species, the shortfin mako shark (), a globally widespread, highly migratory predator, has undergone dramatic population reductions and is now Endangered (IUCN Red List), with Atlantic Ocean mako sharks in particular assessed by fishery managers as overfished and in need of urgent, improved management attention. Genomic-scale population assessments for this apex predator species have not been previously available to inform management planning; thus, we investigated the population genetics of mako sharks across the Atlantic using a bi-organelle genomics approach.
View Article and Find Full Text PDFEcol Evol
January 2025
State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology Chinese Academy of Sciences Wuhan China.
The black bream () is an economically important species widely distributed in China, with its geographic populations potentially having undergone differentiations and local adaptations. In this study, we presented a chromosome-level genome assembly of this species and investigated genetic differentiations of its populations that are allopatric (the northern one) and sympatric (the Poyang Lake) to its kin species, the blunt-snout bream (), using whole genome resequencing analysis. The results showed that the genome size of black bream was 1.
View Article and Find Full Text PDFAnim Biosci
January 2025
Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou Province/Guiyang City/Huaxi District, China.
Objective: This study aimed to identify polymorphisms in the gene encoding the 3-hydroxy-3-methylglutaryl-CoA synthase 1, HMGCS1, and analyze their association with slaughter characteristics, meat quality, and organ coefficients in Guizhou white goats.
Methods: A total of 153 twelve-month-old Guizhou white goats (78 male and 75 female) were included in the study. Slaughter characteristics, meat quality, and organ coefficients were assessed.
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