The new technique of push-and-pull enteroscopy using the double-balloon technique (double-balloon enteroscopy) makes it possible to remove swallowed foreign bodies causing intestinal obstruction deep in the small bowel without the need for surgical laparotomy. This report describes two cases of enteroscopic removal of entrapped capsules. In one patient with acute recurrent intestinal bleeding and recurrent abdominal pain, Crohn's disease had been suspected on capsule endoscopy. The second patient, with known Crohn's disease, was suffering from abdominal pain and underwent capsule endoscopy for investigation of the small bowel. Prior enteroclysis had not revealed stenoses in either patient. An oral approach was chosen and the capsules were identified approximately 140 cm and 310 cm from the pylorus, respectively, in front of stenoses. The capsule endoscopes were removed successfully in both patients by means of push-and-pull enteroscopy using a new enteroscope device.
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http://dx.doi.org/10.1055/s-2005-861320 | DOI Listing |
Front Immunol
March 2025
Department of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Macrophage metabolic reprogramming refers to the process by which macrophages adjust their physiological pathways to meet survival and functional demands in different immune microenvironments. This involves a range of metabolic pathways, including glycolysis, the tricarboxylic acid cycle, oxidative phosphorylation, fatty acid oxidation, and cholesterol transport. By modulating the expression and activity of key enzymes and molecules within these pathways, macrophages can make the transition between pro- and anti-inflammatory phenotypes, thereby linking metabolic reprogramming to inflammatory responses and the progression of several diseases, such as atherosclerosis, inflammatory bowel disease (IBD), and acute lung injury (ALI).
View Article and Find Full Text PDFFront Neurosci
February 2025
Social Brain and Development Lab, School of Psychology, University of Surrey, Guildford, United Kingdom.
Post-traumatic stress disorder (PTSD) is a common mental health disorder that can occur following exposure to a traumatic event, and is characterized by symptoms including intrusive memories, dissociation, and nightmares. PTSD poses significant suffering on the individual and can reduce quality of life substantially, however, its mechanisms are not fully understood. It has also been associated with gut abnormalities, such as with irritable bowel syndrome, indicating possible involvement of the gut microbiome and gut-brain axis.
View Article and Find Full Text PDFInt J Endocrinol Metab
July 2024
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Context: In recent decades, adverse reactions to gluten have increased, collectively known as gluten-related disorders (GRDs). The most prominent GRD is celiac disease (CD), a T-cell-mediated autoimmune-like disorder of the small intestine triggered by the ingestion of gluten proteins in genetically predisposed individuals. Celiac disease is often associated with various autoimmune and idiopathic conditions, including autoimmune thyroid disorders (AITDs).
View Article and Find Full Text PDFClin Transl Sci
March 2025
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Military Medical University, Xi'an, China.
Patients with refractory inflammatory bowel disease (IBD) face difficulty in the treatment strategy. Combined advanced targeted therapies may obtain higher therapeutic efficacy. However, few studies compare the efficacy and safety of dual biologic therapy (DBT) with biologic small-molecule therapy (BMT) for refractory IBD.
View Article and Find Full Text PDFBr J Radiol
March 2025
Division of Cancer & Genetics, School of Medicine, Cardiff University, UK.
Objectives: To evaluate current UK practice for inflammatory bowel disease (IBD) imaging against recommendations from published international literature.
Methods: A retrospective multi-centre audit was undertaken evaluating imaging modalities, protocols and pathways used to investigate IBD both in outpatient and inpatient settings during January-December 2022. Reporting practices and training provisions were also recorded.
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