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| http://dx.doi.org/10.1111/j.1365-2052.2005.01275.x | DOI Listing |
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HGS Promotes Tumor Growth, Whereas the Coiled-Coil Domain and Its Oligopeptide of HGS Suppress It.
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Biomembrane Group, Tokyo Metropolitan Institute of Medical Science, 6-1-2, Kamikitazawa, Setagaya-Ku, Tokyo 113-8613, Japan.
We previously isolated a cDNA clone for galactosylceramide expression factor 1, which is the rat homologue of hepatocyte-growth-factor-regulated tyrosine kinase substrate (HGS) and induces galactosylceramide expression and morphological changes in COS-7 cells, and reported that overexpression of HGS induced morphological changes in canine kidney epithelial MDCK cells. HGS is a component of the endosomal sorting complexes required for transport machinery that mediates endosomal multivesicle body formation. In this study, the overexpression of HGS induced epithelial-mesenchymal transition and caused transformation in MDCK cells, whereas the overexpression of a coiled-coil domain of HGS inhibited induction of epithelial-mesenchymal transition by HGF stimulation.
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One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.
From a One Health perspective, dogs and cats have begun to be recognized as important reservoirs for clinically significant multidrug-resistant bacterial pathogens. In this study, we investigated the occurrence and genomic features of ESβL producing Enterobacterales isolated from dogs, in the province of Imbabura, Ecuador. We identified four isolates expressing ESβLs from healthy and diseased animals.
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Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57 (Viikintie 49), Helsinki FI-00014, Finland.
Canine pyometra is a common and potentially life-threatening reproductive disorder in intact female dogs. This prospective study aimed to (1) investigate the bacterial spectrum and antimicrobial susceptibilities of bacterial isolates from the uterus and urine of dogs with pyometra, (2) assess the clonal relatedness and virulence factors of Escherichia coli isolates from individual dogs, and (3) determine the occurrence of concurrent and persistent bacteriuria or clinical urinary tract infections. Bacterial isolates from 208 uterine and 203 urine specimens collected during pyometra surgery were analyzed.
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Division of Molecular Bacterial Epidemiology and Infectious Diseases, Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, CH-3012 Bern, Switzerland. Electronic address:
NDM-5-producing Escherichia coli are the predominant carbapenemase producers of medical and public health importance. The global spread of bla-containing plasmids in high-risk E. coli clones has been primarily documented in humans and increasingly reported in animals and the environment.
View Article and Find Full Text PDFInvestigation of antimicrobial susceptibility and resistance gene prevalence in Capnocytophaga spp. isolated from dogs and cats and characterization of novel class A β-lactamase CST-1.
Eur J Clin Microbiol Infect Dis
December 2024
Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Article Synopsis
- Capnocytophaga spp. are zoonotic pathogens from the mouths of dogs and cats that can cause serious infections in humans through bites and scratches, highlighting the need for effective antimicrobial treatment due to their rapid symptom onset.
- Resistance and susceptibility to nine antibiotics were tested on 57 isolates from different species of Capnocytophaga using E-test methods, revealing high minimum inhibitory concentrations (MICs) for several antibiotics, while imipenem and amoxicillin/clavulanic acid had low MICs across the board.
- The study identified both known resistance genes and a novel resistance gene (CST-1), which can inactivate penicillin and certain cephalosporins, underscoring the importance of understanding antimicrobial resistance in treating
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