Short and novel stereospecific synthesis of trisubstituted 2,5-diketopiperazines.

J Org Chem

Department of Medicinal Chemistry, Cardiovascular and Urogenital CEDD, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom.

Published: June 2005

Novel syntheses of chiral trisubstituted 2,5-diketopiperazines using multicomponent Ugi reactions were developed.

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Source
http://dx.doi.org/10.1021/jo0501137DOI Listing

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