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Polysaccharide Fraction Isolated from Exhibits Anti-Cancer Effects Through Immunostimulating Activities.
Mar Drugs
January 2025
Department of Food Science and Biotechnology, Kyonggi University, Suwon 16227, Republic of Korea.
The present research aimed to assess the anti-cancer effects of the polysaccharide fraction (SJP) isolated from . The release of immune-activating cytokines, including IL-6, IL-12, and TNF-α, was markedly stimulated by the SJP in a concentration-dependent manner within the range of 1 to 100 µg/mL. Furthermore, the prophylactic intravenous () and per os () injection of SJP boosted the cytolytic activity mediated by NK cells and CTLs against tumor cells.
View Article and Find Full Text PDFSurviving COVID-19 and Battling Fibrosis: A Retrospective Cohort Study Across Three Pandemic Waves.
Diagnostics (Basel)
December 2024
Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, No. 37, Dionisie Lupu Street, Sector 2, 020021 Bucharest, Romania.
Background/objectives: We aimed to characterize the fibrosis following COVID-19 pneumonia, using quantitative analysis, after three months and subsequently, after two years of patients' release from the hospital, and to identify the risk factors for pulmonary fibrosis.
Methods: We performed a retrospective, observational cohort study on 420 patients with severe forms of COVID-19. For all patients, we registered demographic, inflammatory and biochemical parameters, complete blood count and D-dimers; all patients underwent three computed tomography scans (at admittance, at 3 months and at 2 years).
Durlobactam to boost the clinical utility of standard of care β-lactams against lung disease.
Antimicrob Agents Chemother
November 2024
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulmonary infections caused by (Mab). However, their potency against Mab is many-fold lower than against Gram-positive and Gram-negative pathogens for which they were optimized, putting into question their clinical utility.
View Article and Find Full Text PDFMaintenance and functional regulation of immune memory to COVID-19 vaccines in tissues.
Immunity
December 2024
Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Article Synopsis
- Memory T and B cells in tissues are crucial for immunity, with a study analyzing immune memory from mRNA COVID-19 vaccine in 63 organ donors of varying ages.* -
- Spike-reactive memory T cells were found in lymphoid organs and lungs, showing differences in expression based on prior SARS-CoV-2 infection, while B cells in these areas were mainly class-switched memory cells.* -
- Tissue memory T cells lasted longer than blood counterparts, especially in older individuals, with distinct roles: regulatory profiles were more common in tissues, helping protect while minimizing damage.*
Solid cancer-directed CAR T cell therapy that attacks both tumor and immunosuppressive cells via targeting PD-L1.
Mol Ther Oncol
December 2024
Regenerative Immunotherapy and CAR-T Translational Research Program, Mayo Clinic, Jacksonville, FL, USA.
Article Synopsis
- * A new CAR called MC9999 was developed to target both tumor and immunosuppressive cells effectively, demonstrating consistent antitumor effects in models of breast cancer, lung cancer, melanoma, and glioblastoma multiforme (GBM).
- * MC9999 CAR T cells have shown the ability to cross the blood-brain barrier and specifically kill immunosuppressive cells within GBM tumors, highlighting their potential as a foundation for improved CAR
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