Among those drivers responsible for injury-producing traffic crashes in a town of northern Italy (Modena) and its surrounding territory, we evaluated the percentage that was positive for alcohol or other drugs affecting CNS function. A total of 115 crash-responsible injured drivers (90 males and 25 females) consecutively presenting to the emergency department at the University Hospital of Modena were enrolled. A urine sample was requested from each driver; the presence of alcohol or drugs was detected by means of various procedures (enzyme immunoassay, liquid or gas chromatography, mass spectrometry). Among the 115 enrolled drivers, 46 (40%) were positive for at least one drug and/or alcohol. Of these 46 drivers, 66% were positive for a single drug, 25% for two drugs, 9% for three or more drugs. Recent use of marijuana was found most frequently (19% out of the total 115 enrolled drivers), surpassing alcohol (10%), amphetamines (7%) and cocaine (6%); 11 drivers (about 10%) tested positive for benzodiazepines. The majority of drivers positive for benzodiazepines were 41-70 years old, while most drivers positive for alcohol or other drugs were 21-40 years old. Thirty-nine (85%) of the positive injured drivers were males and seven (15%) were females. The present data confirm that a significant percentage of injury-producing traffic crashes involves drivers who are under the influence of drugs of abuse, alcohol, or other drugs affecting the CNS.
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http://dx.doi.org/10.1016/j.drugalcdep.2005.04.010 | DOI Listing |
Sci Rep
January 2025
School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
A nanoemulsion was fabricated from Cananga odorata essential oil (EO) and stabilized by incorporation of Tween 80 using ultrasonication. The major constituents of the EO were benzyl benzoate, linalool, and phenylmethyl ester. Differing sonication amplitude (20-60%) and time (2-10 min) were assessed for effects on nanoemulsion droplet size and polydispersity index (PI).
View Article and Find Full Text PDFChem Biol Interact
January 2025
Anhui Prevention and Control Engineering Research Center for Fatty Liver Disease, Hefei, Anhui, 230032,P. R. China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China. Electronic address:
Oxidative stress induced by excess ethanol is an important factor in the progression of alcoholic liver disease (ALD). In recent years, inhibiting Kelch-like ECH-associated protein 1 (KEAP1) to activate the antioxidant regulator Nuclear factor erythroid 2-related factor 2 (NRF2) has been considered an effective strategy for treating oxidative stress-related diseases, but its application in ALD remains insufficiently explored. This study aims to discover high-affinity inhibitors targeting the KEAP1 receptor.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, Italy.
Background/objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.
View Article and Find Full Text PDFPharmaceutics
January 2025
Institute of Chemistry Rosario, National Council for Scientific and Technical Research (IQUIR-CONICET), Rosario 2000, Argentina.
: Chagas disease is a neglected tropical disease caused by infection with the parasite . Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. This work aimed for the first time to formulate tablets of nifurtimox by hot melt extrusion coupled with 3D printing as a strategy to increase drug dissolution and the production of tablets with dosage on demand.
View Article and Find Full Text PDFPharmaceutics
December 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasília 70910-900, Brazil.
: This study aimed to evaluate the safety and efficacy of chitosan-based bioadhesive films for facilitating the topical delivery of curcumin in skin cancer treatment, addressing the pharmacokinetic limitations associated with oral administration. : The films, which incorporated curcumin, were formulated using varying proportions of chitosan, polyvinyl alcohol, Poloxamer 407, and propylene glycol. These films were assessed for stability, drug release, in vitro skin permeation, cell viability (with and without radiotherapy), and skin irritation.
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