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Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl. | LitMetric
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Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl.

Katja Masjosthusmann Stefan S Bielack Gabriele Köhler Annekathrein Florax Manfred Schiborr Jochen Bruch Dirk Reinhardt Nanna Kuhn Michael Paulussen Herbert Jürgens

Pediatr Blood Cancer

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

Published: November 2005

Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5-year-old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT-PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis.

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http://dx.doi.org/10.1002/pbc.20265DOI Listing

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