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BMP4 regulates differentiation of nestin-positive stem cells into melanocytes.
Cell Mol Life Sci
January 2025
Department of Anesthesiology, Shenzhen Children's Hospital, Yitian Road 7019, Shenzhen, 518000, China.
Hair follicle (HF) development and pigmentation are complex processes governed by various signaling pathways, such as TGF-β and FGF signaling pathways. Nestin + (neural crest like) stem cells are also expressed in HF stem cells, particularly in the bulge and dermal papilla region. However, the specific role and differentiation potential of these Nestin-positive cells within the HF remain unclear, especially regarding their contribution to melanocyte formation and hair pigmentation.
View Article and Find Full Text PDFMusculoskeletal differences in the craniomandibular region of children and adolescents with and without bruxism: A comparative study.
Cranio
January 2025
Department of Physiatry and Nursing, Universidad de Zaragoza, Zaragoza, Spain.
Objective: To analyse the relationship between bruxism and musculoskeletal parameters of the cervical and mandibular regions in children and adolescents.
Methods: A comparative cross-sectional study was performed with subjects from 6 to 16 years. Subjects were divided into bruxism (any type) and control groups.
Ethnobotany of vascular plants use, conservation and management practice in the homegardens by the people of Dawuro in Southwestern Ethiopia.
J Ethnobiol Ethnomed
January 2025
Department of Biology, College of Natural and Computational Science, Arba Minch University, Arba Minch, Ethiopia.
Background: Homegardens (HGs) are well-time-honored traditional land use systems in small plots of land with purposely designed intricate structure and a mixture of planted vascular plants (VPs) for different purposes. Hence, the present study was initiated to investigate the ethnobotanical information of vascular plants of homegardens and their use, conservation and management practice by the people of Dawuro in southwestern Ethiopia.
Methods: A total of 162 farmer informants were selected and interviewed within a distance of < 2 km, 2-4 km and > 4 km between the natural forest and homegardens, and 0.
Enhancing newborn screening sensitivity and specificity for missed NICCD using selected amino acids and acylcarnitines.
Orphanet J Rare Dis
January 2025
Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Purpose: To enhance the detection rate of Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD) through newborn screening (NBS), we analyzed the metabolic profiles of missed patients and proposed a more reliable method for early diagnosis.
Methods: In this retrospective study, NICCD patients were classified into "Newborn Screening" (64 individuals) and "Missed Screening" (52 individuals) groups. Metabolic profiles were analyzed using the non-derivatized MS/MS Kit, and genetic mutations were identified via next-generation sequencing and confirmed by Sanger sequencing.
Association of insulin resistance surrogates with live birth outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.
BMC Pregnancy Childbirth
January 2025
Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Background: Insulin resistance (IR) is a common pathophysiologic feature in patients with polycystic ovary syndrome (PCOS). However, there have been no studies investigating the association of IR surrogates with pregnancy outcomes in women with PCOS undergoing in vitro fertilization (IVF). Therefore, we explored the association between these factors among PCOS patients.
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