The studies covered hemostasis changes in workers with occupational fluorosis. The disorders diagnosed could be a risk factor for IHD in aluminium production workers
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Case report: Mixed hydrofluoric and nitric acid mist inhalation poisoning.
Front Med (Lausanne)
October 2024
Department of Pharmacy, The Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
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- Hydrofluoric and nitric acids are highly corrosive and can cause chemical pneumonia when inhaled, leading to serious respiratory issues and requiring supportive treatment to manage symptoms.* -
- The case study discusses three individuals who suffered from chemical pneumonia after a workplace accident involving a mixture of these acids, highlighting the need for emergency treatments like oxygenation.* -
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Comparative Perceptions of Fluoride Toxicity in Oral Hygiene Products: Insights from the General Population and Healthcare Professionals.
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Department of Restorative Dental Medicine and Endodontics, University of Split School of Medicine, 21000 Split, Croatia.
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- - The study aimed to assess the knowledge and attitudes of dentists, physicians, pharmacists, and the general public about the safety of ingredients in oral hygiene products, specifically focusing on fluoride and its potential toxicity.
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The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
J Hazard Mater
April 2024
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:
Elevated exposures to fluoride have been linked to neurological diseases. Identifying mechanisms of fluoride neurotoxicity and finding ways for prevention and treatment of epidemic fluorosis are important issues of public health. In this study, fluoride inhibited TFEB nuclear translocation by activating p-mTORC1/p-p70S6K, thus inhibiting lysosomal biogenesis, leading to dysfunctional lysosome accumulation, which further negatively affected autophagosome and lysosome fusion, thus impairing autophagy degradation, evidenced by the blocked conversion of LC3II to LC3I, and the increased p62 levels.
View Article and Find Full Text PDFA community-based study of dental fluorosis in rural children (6-12 years) from an aspirational district in Karnataka, India.
Front Public Health
April 2023
Model Rural Health Research Unit, Department of Health Research (Government of India), Sirwar, Raichur, Karnataka, India.
Objectives: The present study was planned to estimate the prevalence of dental fluorosis in 6-12 years of children and its association with various drinking water sources, water, and urine fluoride levels among the subset of children under the umbrella of a larger study to address iodine deficiency disorders and iron deficiency anemia in 17 villages of Manvi and Devadurga talukas of Raichur district of Karnataka.
Methods: Analysis of subset of data and urine samples of children under the umbrella of a larger cross-sectional community-based study was conducted in 17 villages of Manvi and Devadurga taluks of Raichur district. House to house survey was carried out to collect data using a semi-structured questionnaire in ODK software.
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