Background: Identification of children after traumatic brain injury (TBI) likely to have functional deficits at trauma center discharge will facilitate care.
Methods: Two logistic regression models were derived from data on 4,439 children after TBI 7 to 14 years old enrolled in the National Pediatric Trauma Registry between 1994 and 2001 to predict physical and cognitive disabilities.
Results: Children with open or multiple fractures or closed fractures or injured by motor vehicles were 8.2, 3.5, or 2.5 times more likely, respectively, than those without those circumstances to have discharge physical disabilities. Likelihood of cognitive impairment was increased by factors of 3.2 and 5.8 in children obtunded or comatose on arrival. Preexisting cognitive deficits, injury severity, and intubation predicted physical and cognitive disabilities. The C statistic was 0.862 for the motor model and 0.860 for the cognitive model.
Conclusion: Predicting the likelihood of morbidity after acute management of childhood TBI can provide information pertinent to providing effective care.
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http://dx.doi.org/10.1097/01.ta.0000162630.78386.98 | DOI Listing |
Nutrients
December 2024
Department of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
The gut-brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores the complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting its effect on brain health, particularly in the context of depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing its bioavailability and predisposing to neuroinflammation and neurotoxicity.
View Article and Find Full Text PDFNutrients
December 2024
Department of Intensive Care, University Hospital of Foggia, 71121 Foggia, Italy.
Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), and neuroinflammation in the TBI. We delineate the dual aspects of TBI: the immediate mechanical damage (primary injury) and the subsequent biological processes (secondary injury) that exacerbate neuronal damage.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Department of Neurosurgery, Chung Shan Medical University Hospital, Taichung City 402, Taiwan, China.
Traumatic direct type carotid cavernous fistula (CCF) is an acquired arteriovenous shunt between the carotid artery and the cavernous sinus post severe craniofacial trauma or iatrogenic injury. We reported a 46-year-old woman who had developed a traumatic direct type CCF after severe head trauma with a skull base fracture and brain contusion hemorrhage. The clinical manifestations of the patient included pulsatile exophthalmos, proptosis, bruits, chemosis, and a decline in consciousness.
View Article and Find Full Text PDFJ Clin Med
December 2024
Mechanical Engineering Department, Auburn University, Auburn, AL 36849, USA.
The accurate, repeatable, and cost-effective quantitative characterization of mild traumatic brain injuries (mTBIs) is crucial for safeguarding the long-term health and performance of high-risk groups, including athletes, emergency responders, and military personnel. However, gaps remain in optimizing mTBI assessment methods, especially regarding the integration of neuromechanical metrics such as reaction time (RT) in predictive models. This review synthesizes existing research on the use of neuromechanical probabilistic models as tools for assessing mTBI, with an emphasis on RT's role in predictive diagnostics.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Surgery, NYC Health and Hospitals, Elmhurst Hospital Center, New York, NY 11373, USA.
: Despite improvements in technology and safety measures, injuries from collisions involving motor vehicles (CIMVs) continue to be prevalent. Therefore, our goal is to investigate the different patterns of head injuries associated with CIMVs. : This is a single-center, retrospective study of patients with motor vehicle-related trauma between 1 January 2016-31 December 2023.
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