Because of the peculiar reactivity of the idose part of N-Boc neomycin B , special care must be exercised to introduce a substituent at the 5"-position of the antibiotic when using Mitsunobu reaction conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b505280g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reactivity of Mg(AlMe) towards neutral tris(pyrazolyl)alkanes.
Dalton Trans
December 2024
Institut für Anorganische Chemie, Eberhard Karls Universität Tübingen (EKUT), Auf der Morgenstelle 18, 72076, Germany.
Various new tris(pyrazolyl)alkanes of the class R'CTp (R' = Me, Et, Pr, iBu; R = Et, Pr, Cy, BuPh, Ph; Pr = cyclopropyl, Cy = cyclohexyl, BuPh = -butylphenyl) were synthesised and their reactivity towards Mg(AlMe) was examined. Along with new examples of recurring structural motifs, such as separated ion pairs and "metal in a box" complexes, , [(MeCTp)Mg][AlMe], several magnesium complexes with new structural features/compositions were obtained. Treatment of the "metal in a box" species [(MeCTp)Mg][AlMe] with THF donor gave the terminal methyl complex [(MeCTp)MgMe(thf)][AlMe].
View Article and Find Full Text PDFThe Positional Effect of an Immobilized Re Tricarbonyl Catalyst for CO Reduction.
ACS Appl Mater Interfaces
September 2024
Department of Chemistry, University of Southern California, California, Los Angeles 90089, United States.
The storage of renewable energy through the conversion of CO to CO provides a viable solution for the intermittent nature of these energy sources. The immobilization of rhenium(I) tricarbonyl molecular complexes is presented through the reductive coupling of bis(diazonium) aryl substituents. The heterogenized complex was characterized through ultra-visible, attenuated total reflectance, infrared reflection absorption spectroscopy, and X-ray photoelectron spectroscopy to probe the electronic structure of the immobilized complex.
View Article and Find Full Text PDFJulolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers.
Acta Pharm Sin B
July 2024
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
The aggregation-caused quenching (ACQ) rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived interferences. However, its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-I (700-900 nm) bioimaging owing to absorption and diffraction by biological tissues and tissue-derived autofluorescence. This study aimed to develop ACQ-based NIR-II (1000-1700 nm) probes to further improve the imaging resolution and accuracy.
View Article and Find Full Text PDFBlocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile.
Bioorg Chem
July 2024
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298, United States; Institute for Drug and Alcohol Studies, 203 East Cary Street, Richmond, VA 23298-0059. Electronic address:
The number of opioid-related overdose deaths and individuals that have suffered from opioid use disorders have significantly increased over the last 30 years. FDA approved maintenance therapies to treat opioid use disorder may successfully curb drug craving and prevent relapse but harbor adverse effects that reduce patient compliance. This has created a need for new chemical entities with improved patient experience.
View Article and Find Full Text PDFN-Pyrazolyl- and N-Triazolylamines and -Ureas as Antileishmanial and Antitrypanosomal Drugs.
ChemMedChem
August 2024
Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149, Münster, Germany.
Three types of modifications of antileishmanial pyrazole lead compounds 7 and 8 were conducted to expand understanding of the relationships between structural features and antileishmanial/antitrypanosomal activity: (1) the pyrazole core was retained or replaced by a 1,2,4-triazole ring; (2) various aryl moieties including 2-fluorophenyl, pyridin-3-yl and pyrazin-2-yl rings were attached at 3-position of the core azole; (3) either arylmethylamino or ureido substituents were introduced at 5-position of the azole core. The synthesis followed established routes starting with esters 9 or 15 and anhydride 21. The synthesized 3-arylpyrazoles and 3-aryl-1,2,4-triazoles had only very low antileishmanial activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!