Isolation and expression of a novel molecular class D beta-lactamase, OXA-61, from Campylobacter jejuni.

Antimicrob Agents Chemother

Microbial Glycobiology, Institute for Glycomics, Griffith University and Microbiology Department, Queensland Health Pathology Services, Gold Coast Hospital, 108 Nerang St., Southport, Queensland, Australia 4215.

Published: June 2005

A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA-61 is required for expression in Campylobacter.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140520PMC
http://dx.doi.org/10.1128/AAC.49.6.2515-2518.2005DOI Listing

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