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N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA. | LitMetric
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N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.

Hitoshi Suda Akio Kobori Jinhua Zhang Gosuke Hayashi Kazuhiko Nakatani

Bioorg Med Chem

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan.

Published: July 2005

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.

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 Source
http://dx.doi.org/10.1016/j.bmc.2005.04.035DOI Listing

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