AI Article Synopsis
- The study aimed to investigate whether plasma lipoprotein(a) levels are higher in women with pre-eclampsia compared to healthy pregnant women and how these levels relate to the disease's severity.
- Ninety-one women with pre-eclampsia (split into mild and severe cases) and 40 healthy pregnant women were analyzed for various blood parameters, including lipoprotein(a) and lipid levels.
- The results showed no significant difference in lipoprotein(a) levels among the groups, suggesting it is not a key risk factor for pre-eclampsia, though elevated triglyceride levels might contribute to the condition.
Article Abstract
Aim: To determine if plasma lipoprotein(a) levels are elevated in pre-eclampsia and if so, their association with the severity of the disease.
Methods: Ninety-one pre-eclamptic (48 mild, 43 severe) and 40 healthy normotensive pregnant women at more than 32 gestational weeks were recruited into study. Plasma levels of lipoprotein(a), lipids, total protein, albumin and fibrinogen were measured in all subjects.
Results: All groups were comparable with respect to maternal age, maternal weight, gravidity and parity. Platelet count, total serum protein and albumin levels were significantly decreased, whereas fibrinogen levels significantly increased in the pre-eclamptic group. There was no difference between the groups with respect to total cholesterol and low-density lipoprotein levels. In the pre-eclampsic group, triglyceride and very-low-density lipoprotein concentrations were significantly higher, whereas high-density lipoprotein levels were significantly lower. No difference in serum lipoprotein(a) levels was found between the three groups.
Conclusions: No statistically significant difference existed between normotensive pregnant, and pre-eclamptic women, with regard to plasma lipoprotein(a) levels. It is improbable that high serum lipoprotein(a) levels are risk factors for the development of pre-eclampsia; however, elevated triglyceride-rich lipoproteins might cause endothelial damage leading to pre-eclampsia.
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| http://dx.doi.org/10.1111/j.1447-0756.2005.00276.x | DOI Listing |
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