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Background: The Global Matrix initiative provides unique insights into child and adolescent physical activity (PA) worldwide, yet requires substantial human efforts and financial support.
Purpose: This study aimed to evaluate the process and outcomes of the latest edition of the initiative, the Global Matrix 4.0, reflect on its evolution from earlier editions, and provide recommendations for future Global Matrices.
Flow-mediated dilation decreases in women, but not men, following mild acute intermittent hypoxia.
J Appl Physiol (1985)
January 2025
Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland, United States.
Acute, intermittent exposure to mild hypoxia increases sympathetic nervous system activity, decreases arterial shear rate, and increases blood pressure (BP) in young men. Given that the BP-raising effects of intermittent hypoxia (IH) are less evident in young women, we sought to examine the influence of sex on macro- and microvascular function following IH. BP, macrovascular function [brachial artery flow-mediated dilation (FMD)], microvascular function [reactive hyperemia area under the curve (RHAUC)], and brachial artery shear rate [shear rate area under the curve (SRAUC)] were measured before and following 30 min of IH in 18 young adults (8 women, 23 ± 5 yr).
View Article and Find Full Text PDFRelationship between participation in leisure activities and the maintenance of successful aging in older Chinese adults: a 4-year longitudinal study.
BMC Geriatr
December 2024
Faculty of Sports Science, Ningbo University, No. 818 Fenghua Road, Jiangbei District, Ningbo, 315211, Zhejiang, China.
Background: It is critical to age successfully for general health considering the aging of the global population. Successful aging is an important indicator to assess whether older individuals are experiencing a healthy life and high-quality aging. This study aimed to explore the longitudinal relationship between the frequency and number of participation in leisure activities and the maintenance of successful aging.
View Article and Find Full Text PDFValidation of a Community-Based Approach Toward Personalized Dementia Risk Reduction: The Kimel Family Centre for Brain Health and Wellness.
J Prev Alzheimers Dis
October 2024
Nicole D. Anderson, PhD, CPsych, Rotman Research Institute, Baycrest Academy for Research and Education, 3560 Bathurst Street, Toronto, Ontario M6A 2E1,
Article Synopsis
- The Kimel Family Centre is conducting a two-year study to assess personalized dementia risk reduction programs aimed at lowering dementia risk and improving cognitive health in participants aged 50 and older.
- Participants will undergo a thorough dementia risk assessment to receive tailored reports that address their specific health risk factors across five domains: physical activity, nutrition, cognitive engagement, social connections, and mental wellbeing.
- About 450 participants will select programs based on their individual strategies, with assessments happening every six months and annually to track changes in their dementia risk and cognitive health.
Immunogenicity and safety of an ORF7-deficient skin-attenuated and neuro-attenuated live vaccine for varicella: a randomised, double-blind, controlled, phase 2a trial.
Lancet Infect Dis
August 2024
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, Xiamen University, Xiamen, China; The Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences, Xiamen University, Xiamen, China.
Background: The Oka varicella vaccine strain remains neurovirulent and can establish lifelong latent infection, raising safety concerns about vaccine-related herpes zoster. In this study, we aimed to evaluate the immunogenicity and safety of a skin-attenuated and neuro-attenuated varicella vaccine candidate (v7D vaccine).
Methods: We did this randomised, double-blind, controlled, phase 2a clinical trial in Jiangsu, China.
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