AI Article Synopsis
- The study investigated p53 autoantibodies in head and neck cancer patients using various methods like ELISA and Western blot.
- It was found that 8.2% of patients produced antibodies against p53, with these antibodies recognizing common epitopes that are also targeted by established monoclonal antibodies.
- These common epitopes are important for p53's function in regulating cell growth, suggesting their potential usefulness in developing new cancer therapies.
Article Abstract
In the present study, we analysed p53 autoantibodies from patients with head and neck cancer by ELISA, by Western blot using C- and N-terminal fragments of p53 and with peptide libraries of p53. We found that 8.2% of the patients with head and neck cancer developed antibodies against p53. Using additional p53 autoantibody-positive sera from patients with head and neck cancer, we found that all of these sera recognised common epitopes, which were also recognised by well-known mouse monoclonal antibodies against p53. Common epitopes are located in regions on the polypeptide chain of p53, which are functionally important for the role of p53 in growth control. Thus, the knowledge of these epitopes might be useful for the development of new strategies for cancer therapy.
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| http://dx.doi.org/10.1016/j.canlet.2005.02.040 | DOI Listing |
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