New bis-pyridinium oxime reactivators connected with a CH(2)CH(2)OCH(2)CH(2) linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M.
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Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.
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Eur J Med Chem
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Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005, Hradec Kralove, Czech Republic. Electronic address:
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Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, MS, 39762, United States. Electronic address:
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Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Bijnor-Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow, Uttar Pradesh 226002, India.
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