A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.
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| http://dx.doi.org/10.1016/j.bmcl.2005.04.002 | DOI Listing |
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