Introduction: Laparoscopic hysterectomy (LH) is a safe surgical approach that offers patients a faster recovery. However, its use in malignant or premalignant gynecological lesions is not well established. The objective of the present study was to show the feasibility of LH in a tertiary cancer center.
Material And Methods: We conducted a descriptive analysis of patients with histologically proven malignant or premalignant uterine lesions who underwent to LH. Surgical time, bleeding complications, and hospital stay were evaluated.
Results: Twenty-five patients were included with a mean age of 45 years. Ten LH (40%) with or without salpingo-oophorectomy for premalignant or preinvasive malignant lesions were done, five surgical staging procedures for endometrial cancer (20%) and seven radical hysterectomies for cervical cancer (28%). In three patients, conversion from laparotomy (12%) was necessary for operative complications (two cases) or technical problems (one case). Mean operative time for the entire group was 207 min, mean bleeding 204 mL and mean hospital stay was 2.5 days. Postoperative complications were present in two patients, hematoma in the vaginal cupola (one case) and temporary bladder dysfunction (one case).
Conclusions: In the present trial we described our initial experience in LH for the treatment of malignant and premalignant gynecologic diseases. Our results suggest that it is a safe and feasible surgical approach. Long-term surveillance studies are necessary for the evaluation of recurrence patterns and overall survival.
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BMC Cancer
December 2024
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.
Background: This study aimed to investigate the potential utility of Epithelial-mesenchymal transition (EMT) signaling cell detection in the early diagnosis of cervical lesions.
Methods: Enrichment of cervical epithelial cells was carried out using a calibrated membrane with 8-μm diameter pores. RNA-in situ hybridization (RNA-ISH) was employed to detect and characterize EMT cells utilizing specific EMT markers.
Sci Rep
December 2024
Univ. Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, 38000, France.
Xeroderma pigmentosum group C (XPC) is a versatile protein crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with environmental factors, such as exposure to ultraviolet (UV) radiation from the sun. Loss-of-function mutations in the XPC gene confer a photosensitive phenotype in XP-C patients, resulting in the accumulation of unrepaired UV-induced DNA damage.
View Article and Find Full Text PDFClin Lymphoma Myeloma Leuk
December 2024
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT; Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT. Electronic address:
Monoclonal gammopathy of undetermined significance (MGUS) is a pre-malignant condition of multiple myeloma (MM). Evidence suggested old age, black race, male gender, and obesity as risk factors for MGUS development; however, whether they are associated with an increased risk of progression to MM among patients with MGUS is unclear. A systematic search of PUBMED and EMBASE for cohort studies investigating the association between age/race/gender/obesity and progression to MM.
View Article and Find Full Text PDFInt J Oral Maxillofac Surg
December 2024
Department of Head and Neck Tumors, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. The development and progression of OSCC are closely linked to various aetiological factors. Early signs of OSCC may manifest as oral lesions, genetic abnormalities, and chronic inflammation.
View Article and Find Full Text PDFEJNMMI Res
December 2024
Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Background: To intraindividually compare the diagnostic performance of positron emission computed tomography (F-18-FDG-PET/CT) and diffusion-weighted magnetic resonance imaging (DW-MRI) in a non-inferiority design for the discrimination of peripheral nerve sheath tumours as benign (BPNST), atypical (ANF), or malignant (MPNST) in patients with neurofibromatosis type 1 (NF1).
Results: In this prospective single-centre study, thirty-four NF1 patients (18 male; 30 ± 11 years) underwent F-18-FDG-PET/CT and multi-b-value DW-MRI (11 b-values 0 - 800 s/mm²) at 3T. Sixty-six lesions corresponding to 39 BPNST, 11 ANF, and 16 MPNST were evaluated.
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