The aim was the study of the connection of the changes in serum homocysteine concentration with acute myocardium infarction, in order to establish whether the increase in homocysteine concentration is one of the risk-factors in the development of the cardiac insufficiency. The patients with acute myocardial infarction were studied. The following tests were performed: determination of the homocysteine concentration in serum by ELISA; determination of the main characteristics of hemostasis by automatic coagulometer (AMELUNG); determination of lipid spectrum by biochemical analyzer (Johnson & Johnson Vitros DT). The results obtained allowed us to suggest that the changes in the serum homocysteine concentration in patients with myocardial infarction occur in accordance with the changes in the protective mechanisms of the organism, and it may be used for the diagnostics of weakening and strengthening of the processes of arteriosclerosis and thrombosis.
Download full-text PDF |
Source |
---|
Metabolites
January 2025
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, 40-752 Katowice, Poland.
Untreated hyperprolactinemia and autoimmune thyroiditis (Hashimoto's disease) seem to increase cardiometabolic risk. The cardiometabolic effects of cabergoline were less significant in young women with concurrent euthyroid Hashimoto's illness. This study sought to investigate if the detrimental effects of this condition on cabergoline efficacy are also evident in postmenopausal women.
View Article and Find Full Text PDFSmall
January 2025
Analytical & Environmental Science Division and Centralized Instrument Facility, CSIR-CSMCRI, G. B. Marg, Bhavnagar, 364002, India.
The present work reports the synthesis, characterization, and excited state photo-physical studies of two copper(II) compounds, 1 & 2, which show interference-free emission with homocysteine (Hcy). Cu(II) complexes offer an orthogonal detection strategy involving fluorescence and electrochemical methods, paving the way for improved point-of-care diagnostics and early cardiovascular diseases intervention. The reduction-induced emission enhancement (RIEE) of Cu complexes facilitates the fluorescence measurement of Hcy at physiological pH.
View Article and Find Full Text PDFAppl Environ Microbiol
January 2025
Institute for Chemistry and Biology of the Marine Environment (ICBM), School of Mathematics and Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Vitamin B (cobalamin, herein B) is a key cofactor for most organisms being involved in essential metabolic processes. In microbial communities, B is often scarce, largely because only few prokaryotes can synthesize B and are thus considered B-prototrophs. B-auxotrophy is mostly manifested by the absence of the B-independent methionine synthase, MetE.
View Article and Find Full Text PDFGenes Nutr
January 2025
Department of Nutrition, University of Oslo (UiO), Oslo, Norway.
Background: One-carbon metabolism links folate and methionine metabolism and this is essential for nucleotide synthesis in the cells. Alterations in one-carbon metabolism are associated with cardiovascular disease (CVD), type 2 diabetes and cancer. Our aim was to investigate whether SNPs in antioxidant-enzyme genes impact the concentrations of folate in serum (s-folate), plasma total homocysteine (p-tHcy) and total glutathione in plasma (p-tGSH) in healthy subjects after supplementation with folic acid.
View Article and Find Full Text PDFBackground: One-carbon metabolism (OCM), a biochemical pathway dependent on micronutrients including folate and vitamin B12, plays an essential role in aging-related physiological processes. DNA methylation-based aging biomarkers may be influenced by OCM.
Objective: This study investigated associations of OCM-related biomarkers with epigenetic aging biomarkers in the National Health and Nutrition Examination Survey (NHANES).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!