AI Article Synopsis
- The vertebra forms from the sclerotome, the ventral section of the somite, influenced by signaling molecules from neighboring tissues.
- The article aims to explore the processes of sclerotome induction, chondrogenesis, and morphogenesis related to vertebra development.
- It highlights how combining traditional embryology with modern genetic techniques has enhanced our understanding of the various stages involved in vertebra formation.
Article Abstract
The vertebra develops from the ventral part of the somite, the sclerotome. Sclerotome progenitors are subject to multiple signaling molecules secreted by the adjacent tissues that control their fate. The aim of this article is to discuss the mechanisms of sclerotome induction, chondrogenesis and morphogenesis. By integrating the results from classical studies and recent molecular advances, this will illustrate how the powerful combination of experimental embryology and genetic approaches has recently illuminated the multiple steps of vertebra formation.
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| http://dx.doi.org/10.1387/ijdb.041953am | DOI Listing |
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