AI Article Synopsis
- The empty follicle syndrome (EFS) is when no eggs are retrieved during repeated ovulation induction despite attempts.
- The study investigates a potential link between EFS and a chromosomal abnormality known as a pericentric inversion of chromosome 2.
- A case report details a woman with multiple unsuccessful IVF attempts due to missing eggs and cells, revealing a possible genetic influence on EFS.
Article Abstract
The empty follicle syndrome (EFS) is defined as a lack of retrieved oocytes from follicles, at the time of repeated aspiration and flushing, following ovulation induction. The actual mechanism responsible for the EFS is still unknown. The aim of this study was to offer more information regarding the possible connection of this syndrome with pericentric inversion of chromosome 2. We give a case report of a patient who had multiple failed IVF attempts, due to the absence of oocyte and granulosa cells in the follicular fluid, following oocyte retrieval in both stimulated and natural cycles. Chromosomal analysis showed the presence of a pericentric inversion of chromosome 2: 46,XX,inv(2)(p11q21) in the female partner karyotype, while the male partner had a normal karyotype. Our case showed possible genetic factor influence in the aetiology of EFS.
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