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Coenzyme Q10 Alleviates Silicosis Fibrosis Inhibiting Ferroptosis in Mice.
In Vivo
December 2024
College of Biology, Hunan University, Changsha, P.R. China;
Background/aim: Silicosis, the most severe type of occupational pneumoconiosis, leads to diffuse pulmonary fibrosis without specific therapy. Ferroptosis is triggered by reactive oxygen species (ROS) and Fe overload-induced lipid peroxidation, which is involved in the progression of pulmonary fibrosis. As an important coenzyme in the process of aerobic respiration, Coenzyme Q10 (CoQ10) can enhance mitochondrial function and energy supply and reduce malondialdehyde (MDA) to limit the risk of fibrosis.
View Article and Find Full Text PDFGene Expression Profiles in Ovarian Cancer Tissues as a Potential Tool to Predict Platinum-based Chemotherapy Resistance.
Anticancer Res
January 2025
Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Background/aim: Ovarian cancer (OC) is one of the leading gynecological causes of death among women. The current standard treatment for OC is debulking surgery followed by platinum-based chemotherapy treatments; however, despite initial success to treatment many patients experience relapses. Currently, there are no available tests to predict sensitivity or resistance to chemotherapy.
View Article and Find Full Text PDFImpact of Rhenium(I)-Diselenoether Compound on Cell Adhesion, Migration, Invasion Capacities, and MMP-2 Release in MDA-MB-231 Breast Cancer Cells.
Anticancer Res
January 2025
School of Allied Healthcare and Sciences, Jain (deemed to be) University, Bangalore, India
Background/aim: Organometallic complexes can decrease adhesion, migration, invasion of cancer cells, mainly through regulation of the extracellular matrix and therefore act against metastases. The aim was to investigate the anti-invasive properties of a rhenium-based metal compound, rhenium(I)-diselenoether (Re-diSe) and its effects on matrix metalloproteinase MMP-2, a key player in metastatic processes, in cultured MDA-MB231 triple-negative breast cancer cells.
Materials And Methods: Matrigel was utilized to assess cancer cell adhesion to the extracellular matrix.
A review of chitosan role in milk bioactive-based drug delivery, smart packaging and biosensors: Recent advances and developments.
Int J Biol Macromol
December 2024
Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran. Electronic address:
Chitosan, a versatile biopolymer derived from chitin, is increasingly recognized in the milk industry for its multifunctional applications in drug delivery, smart packaging, and biosensor development. This review provides a comprehensive analysis of recent advances in chitosan production techniques. These include chemical, biological, and novel methods such as deep eutectic solvents (DES), microwave-assisted approaches, and laser-assisted processes.
View Article and Find Full Text PDFPlant species determine elementome differentiation and element coupling during deadwood decay.
Sci Total Environ
December 2024
Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610299, China. Electronic address:
The elemental dynamics and interactions within deadwood profoundly influence carbon sequestration and nutrient cycling in forest ecosystems. Recent studies have investigated macronutrient cycling during deadwood decay of specific plants, yet the dynamics and interactions of micronutrients, trace elements, and the elementome across species and decay stages remain unexplored. Here, we investigated the elementome and their coupling relationships across five decay stages of downed deadwood (DDW) from four dominant species (Hippophae rhamnoides, Populus purdomii, Abies fabri, and Picea brachytyla) along the Hailuogou Glacier primary successional chronosequence.
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