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[Infant botulism: an underestimated problem. A review].
Ter Arkh
December 2024
Izhevsk State Medical Academy.
The article is devoted to a form of botulism that has been little studied in our country and is registered exclusively in infants. The fundamental difference between this form and the most common foodborne botulism is that infants become infected by ingestion of spores, followed by their germination, colonization of the intestines and production of botulinum toxin , which leads to the development of life-threatening flaccid paralysis. Taking into account the peculiarities of pathogenesis, the clinical manifestations of infant botulism have some features, which are discussed by the authors.
View Article and Find Full Text PDFWearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism.
Adv Sci (Weinh)
December 2024
Medical School, Henan University, Kaifeng, Henan Province, 475004, P. R. China.
Accurately assessing potential side effects following botulinum neurotoxin (BoNT) injection remains a formidable challenge. To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophisticated volatilomics technique, aimed at facilitating the rapid and convenient prediction of potential physical discomfort related to latrogenic botulism. The investigation identifies five volatile organic compounds (VOCs)-acetone, styrene, ethanol, 2-pentanone, and n-butano-as promising markers indicative of BoNT poisoning.
View Article and Find Full Text PDFIatrogenic Botulism Following Botulinum Toxin Injection as an Adjunct to Abdominal Wall Reconstruction for Incisional Hernia.
Cureus
November 2024
General Surgery, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Open ventral hernia repair is one of the most commonly performed surgeries by general surgeons worldwide. In the case of complex incisional hernias, there are adjunct techniques that can help abdominal wall reconstruction surgery, such as type A botulinum toxin (BTA), whose injection results in muscle relaxation and growth of muscle fiber length, allowing fascial closure without the need for advanced techniques. We report a case of a male patient who underwent ultrasound-guided BTA injection in the abdominal wall and, five days later, was admitted to our emergency department with dysarthria, muscular weakness, dyspnea on small exertion, and constipation.
View Article and Find Full Text PDFSiO/Si interferometers designed for on-site botulinum neurotoxin serotypes B and C quantification and biological activity assessment.
Biosens Bioelectron
December 2024
Institute of Agricultural Engineering, ARO, Volcani Institute, Rishon LeZion, 7505101, Israel. Electronic address:
Botulinum neurotoxins (BoNT), the agent causing botulism, exhibit the highest potency among bacterial toxins and pose a significant threat to both humans and animals. The current in vivo method (mouse lethality assay, MLA) is inappropriate for real-time and pen-side assessment of the occurring outbreak or case. Herein, we describe a reflective-based biosensor capable of detecting the toxin's type and activity state by competitive immunoassay and endopeptidase activity, respectively.
View Article and Find Full Text PDFTowards safer practices: A spotlight on foodborne botulism following the recent outbreak in Saudi Arabia in 2024.
New Microbes New Infect
December 2024
Research, Policy, and Training Directorate, Jordan Center for Disease Control (JCDC), 11183 Amman, Jordan.
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