Peptide microcin J25 (MccJ25) inhibits bacterial RNA polymerase. We show that thermolysin-cleaved MccJ25 and MccJ25 lacking amino acids 13 to 17 also inhibit transcription. Our data and structural analysis of intact and thermolysin-digested MccJ25 suggest that distinct regions of MccJ25 are involved in transcription inhibition and cell entry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112051 | PMC |
| http://dx.doi.org/10.1128/JB.187.11.3859-3863.2005 | DOI Listing |
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