AI Article Synopsis
- A new rat animal model using genetically modified k-ras-induced rat kidney cells (RK3E-ras) has been developed for studying cancer invasion and metastasis.
- Researchers observed the formation of tumors just 3 days after injecting these cells, with significant growth noted over 2 weeks.
- This model allows for effective study of cancer processes and can be used for rapid testing of various cancer treatment strategies.
Article Abstract
Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague-Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.
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| http://dx.doi.org/10.1016/j.canlet.2005.04.003 | DOI Listing |
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