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Identification of a Novel RUNX1::STX2 Fusion in Mixed-Phenotype Acute Leukemia (MPAL) With BCR::ABL1.
Mol Carcinog
February 2025
Department of Hematopathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia (AL), MPAL with BCR::ABL1 fusion is the main subtype of MPAL, mainly affecting adult males. It is an acute leukemia with unique clinical and biological characteristics that involve both the myeloid and lymphatic systems. Gene fusion plays a crucial role in the pathogenesis, diagnosis, prognosis assessment, and treatment of leukemia.
View Article and Find Full Text PDFSpindle Cell Neoplasms Unique to the Sinonasal Tract.
Surg Pathol Clin
December 2024
Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, 445 Great Circle Road, Office 1959, Nashville, TN 37228, USA.
Article Synopsis
- - The spindle cell neoplasms encompass three main types: sinonasal tract angiofibroma (STA), glomangiopericytoma (GPC), and biphenotypic sinonasal sarcoma (BSNS), which share similarities in their clinical and biological features.
- - Sinonasal tract angiofibroma (STA) is characterized by a collagen-rich, vascular stroma often linked to hormonal changes.
- - Glomangiopericytoma (GPC) has a distinct appearance with a consistent ovular shape and shows Beta-catenin accumulation, while biphenotypic sinonasal sarcoma (BSNS) displays characteristics resembling neural tissue and co-expresses S100 and smooth muscle markers along with
Biphenotypic sinonasal sarcoma diagnosed by detection of fusion gene using integrated whole-genome and transcriptome sequencing.
Int Cancer Conf J
October 2024
Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo Nagaizumi-Cho Sunto-Gun, Shizuoka, 411-8777 Japan.
Biphenotypic sinonasal sarcoma (BSNS) is a double-phenotype sarcoma that shows differentiation in both the nervous and muscular systems. To date, whole-genome and transcriptome sequencing (WGTS) has not been used to analyze BSNS. We report a patient with BSNS who was diagnosed based on rearrangement using WGTS.
View Article and Find Full Text PDFFurosemide‑induced eradication of myeloblasts via the inhibition of tumor necrosis factor‑α expression in a patient with acute biphenotypic leukemia: A case report.
Oncol Lett
December 2024
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402306, Taiwan, R.O.C.
The present study reports the potential of furosemide therapeutic activity in acute myeloid leukemia. A 26-year-old man with acute biphenotypic leukemia was treated with furosemide for suspected pulmonary edema, which was later deemed to be an infiltration of leukemia cells. Notably, the myeloblast population was rapidly eliminated during furosemide therapy.
View Article and Find Full Text PDFMultiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia.
Nat Commun
September 2024
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Despite recent work linking mixed phenotype acute leukemia (MPAL) to certain genetic lesions, specific driver mutations remain undefined for a significant proportion of patients and no genetic subtype is predictive of clinical outcomes. Moreover, therapeutic strategy for MPAL remains unclear, and prognosis is overall poor. We performed multiomic single cell profiling of 14 newly diagnosed adult MPAL patients to characterize the inter- and intra-tumoral transcriptional, immunophenotypic, and genetic landscapes of MPAL.
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