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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A.
Bioimpacts
December 2023
State Research Center for Applied Microbiology and Biotechnology (SRCAMB), Obolensk 142279, Russia.
Article Synopsis
- Botulinum neurotoxins (BoNTs) are highly potent natural toxins, and neutralizing monoclonal antibodies (MAbs) offer an effective immunotherapy against them, with hybridoma technology being the go-to method for MAb production.
- In this study, researchers isolated plasmablasts and activated memory B-cells from a donor who had received BoNT/A injections, then fused them with a cell line to create hybridomas that produce native human MAbs specific to BoNT/A.
- Three hybridomas were successfully created, one of which (1B9) not only binds effectively to BoNT/A but also inhibits its catalytic activity, showing promise for effective treatment even in cases of low
Detection of in Some Egyptian Fish Products, Its Control In Vitro Using Leaves Extracts, and Applicability of Leaf Extract in Tuna.
Foods
March 2023
MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.
This study aims to detect and its control using natural leaf extracts of , , and in Egyptian fish products, e.g., canned tuna, canned sardine, canned mackerel, fesikh, moloha, and renga, as well the application of in tuna.
View Article and Find Full Text PDFBotulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997-2019.
Toxins (Basel)
December 2022
Department of Communicable Diseases, National Centre of Epidemiology, Instituto de Salud Carlos III, C/Monforte de Lemos 5, Pabellón 12, 28029 Madrid, Spain.
Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by . There are different routes of acquisition, food-borne and infant/intestinal being the most frequent presentation, and antitoxin is the treatment of choice in all cases. In Spain, botulism is under surveillance, and case reporting is mandatory.
View Article and Find Full Text PDFPurpose Of Review: This article reviews the pathophysiology, epidemiology, clinical features, diagnosis, and treatment of Lambert-Eaton myasthenic syndrome (LEMS) and botulism, presynaptic disorders of neuromuscular transmission in which rapid diagnosis improves long-term outcomes.
Recent Findings: Therapy for LEMS has seen significant advances in recent years due to the approval of amifampridine-based compounds. LEMS is likely still underdiagnosed, particularly when no underlying malignancy is identified.
Inadequate Refrigeration of Some Commercial Foods Is a Continued Cause of Foodborne Botulism in the United States, 1994-2021.
Foodborne Pathog Dis
June 2022
Centers for Disease Control and Prevention, Enteric Diseases Epidemiology Branch, Atlanta, Georgia, USA.
Foodborne botulism is a rapidly progressive potentially fatal paralyzing illness caused by the consumption of botulinum neurotoxin, which is most commonly produced by Refrigeration is the primary barrier to botulinum neurotoxin production in many processed foods. toxin production has occurred and caused botulism in the United States when foods that were not processed to destroy spores of were stored in an anaerobic environment and not properly refrigerated. We identified 37 cases, including 4 deaths, that occurred during 1994-2021 in the United States from 13 events associated with inadequate refrigeration of commercially produced products.
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