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Microneedle drug delivery system based on hyaluronic acid for improving therapeutic efficiency of hypertrophic scars.
Int J Biol Macromol
January 2025
School of Pharmacy, Xiamen Medical College, Xiamen 361023, PR China; School of Pharmacy, Fujian Medical University, Fuzhou 350108, PR China; Research Center for Sustained and Controlled Release Formulations, Xiamen Medical College, Xiamen 361023, PR China; Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Xiamen 361023, PR China. Electronic address:
Hypertrophic scar (HS) is a disease with excessive skin fibrosis and collagen disorder, which is generally caused by abnormal wound repair process after burn and trauma. Although intralesional injection of 5-fluorouracil (5-Fu) has been used in clinical treatment of HS, the patients' compliance of injection treatment is poor. In this study, a double-layer dissolution microneedle (MN) containing asiaticoside (AS) and 5-Fu was designed for the treatment of HS.
View Article and Find Full Text PDFPathological-microenvironment responsive injectable GelMA hydrogel with visualized biodegradation for pressure-assisted treatment of hypertrophic scars.
Int J Biol Macromol
December 2024
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430022, China; Hubei Engineering Research Center for Skin Repair and Theranostics, Wuhan 430022, China. Electronic address:
Intralesional injection of 5-fluorouracil for the clinical treatment of hypertrophic scars (HS) remains challenging due to its short half-life, as well as the absence of evidence-based dosage and frequency injection guidelines. Herein, we developed a matrix metalloproteinases (MMPs)/reactive oxygen species (ROS)-responsive injectable prodrug hydrogel (GFP) that exhibits sustained drug release and fluorescence imaging capability, aiming to facilitate the optimization of injection dosage and frequency in HS treatment. The GFP hydrogel comprises gelatin methacryloyl and pendant methacryloyl-decorated tetrapeptide (PPPK) with 5-fluorouracil acetic acid/rhodamine B at the N-terminus.
View Article and Find Full Text PDFManagement of Keloids and Hypertrophic Scars.
Am Fam Physician
December 2024
Full Circle Health, Boise, Idaho.
Keloid and hypertrophic scars are a result of aberrant wound healing responses within the reticular dermis. They are thought to be secondary to the formation of a disorganized extracellular matrix due to excessive fibroproliferative collagen response. Prevention of these scars focuses on avoiding elective or cosmetic procedures such as piercings in patients at high risk, reducing tension across the lesion, and decreasing the inflammatory response.
View Article and Find Full Text PDFTreatment of Delayed Hypersensitivity After Injection of Nasal Fillers.
J Cosmet Dermatol
December 2024
Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- Soft tissue filler injections, popular for cosmetic procedures, can lead to adverse reactions, particularly augmentation rhinoplasty in Asian countries due to low nasal bridges.
- There is a need for effective treatments for such reactions, as the complications can severely impact a patient's quality of life.
- A study found that a combination of specific medications resulted in successful treatment of swelling and deformity in two patients, with no side effects after the regimen.
Corticosteroid Atrophy Plaque on the Scalp Treated with 5-Fluourouracil and Bleomycin Infusion in the MMP Technique.
Skin Appendage Disord
October 2024
Department of Dermatology, Hospital Universitário Júlio Muller/Universidade Federal do Mato-Grosso, Cuiabá, Brazil.
Article Synopsis
- Alopecia areata (AA) significantly affects patients' quality of life, and intralesional corticosteroid therapy is commonly used as the initial treatment, though it can lead to skin thinning as a side effect.
- This case study highlights a patient with plaque AA on their forehead who experienced skin atrophy from corticosteroid injections.
- The patient's condition improved dramatically with alternative treatment using 5-Fluorouracil and Bleomycin through a method called Microinfusion of Medicines into the Skin, resulting in complete and lasting hair regrowth.
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