How might cohesin hold sister chromatids together?

Philos Trans R Soc Lond B Biol Sci

IMP (Research Institute of Molecular Pathology), Dr Bohr-Gasse 7, A-1030 Vienna, Austria.

Published: March 2005

The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569479PMC
http://dx.doi.org/10.1098/rstb.2004.1604DOI Listing

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