AI Article Synopsis
- Disseminated Trichosporon infections are serious, especially in neutropenic patients, and typically have a poor outlook.
- A case study is presented where a boy with leukemia had Trichosporon asahii infection that didn't respond to liposomal amphotericin B but improved with voriconazole.
- Voriconazole showed effective results, suggesting it could be a valuable treatment for these infections in patients with blood cancers, warranting further research.
Article Abstract
Disseminated Trichosporon infection in neutropenic patients carries a poor prognosis. Clinical evidence on the use of voriconazole for this infection is limited. The authors report a case of Trichosporon asahii fungemia refractory to liposomal amphotericin B treatment in a boy with acute lymphoblastic leukemia, which resolved after the addition of voriconazole. Both voriconazole and amphotericin B exhibited low minimal inhibitory concentrations and minimal fungicidal concentrations, and their combination was indifferent in vitro. The use of voriconazole for the treatment of trichosporonosis in patients with hematologic malignancies deserves further study.
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| http://dx.doi.org/10.1097/01.mph.0000164865.70522.d7 | DOI Listing |
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