Dercum's disease (adiposis dolorosa, lipomatosis dolorosa morbus Dercum), is a rare disorder resulting in painful fatty deposits around the upper legs, trunk, and upper arms. The portrait painted of Dercum's disease is very complicated, with many other disorders seen associated with the disease. There are no clear pathological mechanisms known, although it is suspected that there is either a metabolic or autoimmune component involved. Here, the authors review the literature to date, including some information from their own studies. In particular, the authors will look at the different strands of evidence pointing to the pathological mechanism of the disorder.
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Introduction: Dercum's disease, also known as adiposis dolorosa, is a rare syndrome characterized by the growth of multiple, and painful, subcutaneous adipose tissues that commonly present in the abdomen and extremities. The scientific community hypothesizes that Dercum's disease is a combination of neurologic and endocrine disorders. Patients commonly describe it as chronic adipose pain, which manifests as sporadic painful flares throughout their history with the disease.
View Article and Find Full Text PDFInfliximab-Induced Improvement in Dercum's Disease.
Cureus
June 2024
Rheumatology, University of Illinois Chicago, Chicago, USA.
Dercum's disease (DD) is a rare and poorly understood disease characterized by obesity and painful lipomas throughout the body. Although the entity is well described in the literature, its etiology, prevalence, and treatment remain unclear. Currently, treatment is focused on pain management.
View Article and Find Full Text PDFLipomatoses.
Ann Endocrinol (Paris)
June 2024
CHU Lille, Endocrinology, Diabetology and Metabolism, 59000 Lille, France; University Lille, 59000 Lille, France; Inserm U1190, 59000 Lille, France; Competence center PRISIS, Endocrinology and Metabolism Department, CHU, Lille, France. Electronic address:
Article Synopsis
- * These conditions can arise in people without obesity, may have genetic links, and usually differ from lipodystrophy syndromes, which involve areas of fat loss.
- * The review discusses various forms of lipomatosis, including isolated conditions like Madelung disease and syndromic forms associated with genetic disorders, and highlights their potential impact on health and appearance.
More than mere lipomas?
J Dtsch Dermatol Ges
April 2024
Dermatology Unit, IRCSS AOU di Bologna, Bologna, Italy.
Familial multiple lipomatosis associated with multiple cherry hemangiomas and moles: a rare case report.
J Surg Case Rep
February 2024
Tbilisi State Medical University, Tbilisi 0186, Georgia.
Article Synopsis
- Lipomas are benign tumors that are quite common, while lipomatoses are rarer types of growths.
- Familial multiple lipomatosis (FML) is a rare genetic condition marked by having many painless lipomas, and it may be linked to other health issues.
- The case report discusses a specific instance of FML that was incorrectly identified as dercum's disease, highlighting the importance of accurate diagnosis.
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