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The Mucosal Protection in the Treatment of Erosive Reflux Esophagitis: Mechanisms for Restoring Epithelial Permeability. A Randomized Clinical Trial.
J Gastrointestin Liver Dis
December 2024
Omsk State Medical University, Omsk, Russia.
Background And Aims: Gastroesophageal reflux disease (GERD) is widespread in the population and is characterized by the risk of developing Barrett's esophagus and associated adenocarcinoma. Key factors in the progression of the disease are not only the frequency and duration of reflux episodes, but also the resistance of the esophageal mucosa to aggressive reflux molecules. Assessment of the state of tight junction proteins, the rate of their recovery under the influence of various treatment regimens is an urgent task for choosing optimal approaches to curing patients with GERD.
View Article and Find Full Text PDFMedication use and risk of reflux oesophagitis.
BMJ Open Gastroenterol
December 2024
Department of Gastroenterology, National Center for Global Health and Medicine, Shinjuku-ku, Japan
Objective: Reflux oesophagitis (RO) is one of the most common diseases encountered by gastroenterologists and primary care physicians. However, few epidemiological studies have investigated the association of medication use and RO. This study aimed to investigate the prevalence of RO and its risk factors, particularly with respect to medication use.
View Article and Find Full Text PDFMechanism of Action of Tongjiang Mixture for Treating Reflux Esophagitis: A Study Using Serum Pharmacochemistry and Network Pharmacology.
Adv Biol (Weinh)
January 2025
Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210012, China.
Tongjiang Mixture (TJM) is a traditional Chinese formula for treating reflux esophagitis (RE). Nevertheless, its active ingredients and potential pharmacological mechanisms are not yet clearly elucidated. This study will identify the active ingredients of TJM using serum pharmacochemistry and to elucidate the mechanism on RE through network pharmacology.
View Article and Find Full Text PDFPrevalence of common upper gastrointestinal diseases in Chinese adults aged 18-64 years.
Sci Bull (Beijing)
December 2024
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address:
Article Synopsis
- A community-based study was conducted in China to assess the prevalence of GERD, reflux esophagitis, gastric and duodenal ulcers, as well as Helicobacter pylori infection among adults aged 18-64, involving 27,637 participants from 2017 to 2018.
- The study found prevalence rates of 10.5% for GERD, 5.4% for reflux esophagitis, 2.5% for gastric ulcers, 4.5% for duodenal ulcers, and 41.5% for H. pylori infection, with specific regions showing varying rates.
- Common risk factors identified for GERD, reflux esophagitis, and gastric ulcers included
Complex upper gastrointestinal bleeding: A case of combined peptic ulcer disease and ruptured gastroduodenal artery aneurysm in a pediatric patient.
Radiol Case Rep
January 2025
City Children's Hospital, Ho Chi Minh City, Viet Nam.
Upper gastrointestinal (GI) bleeding in older children is generally caused by conditions like esophagitis, esophageal variceal rupture, and peptic ulcer disease. However, it is rare for bleeding to result from a ruptured vascular aneurysm of the gastroduodenal artery, particularly when associated with peptic ulcer disease. This report describes a case involving a 13-year-old male who presented with severe upper GI bleeding and hemodynamic instability, requiring blood transfusion.
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