AI Article Synopsis
- Researchers discovered two CB1 genes in the fish Fugu rubripes, revealing that the endocannabinoid system is highly conserved across species.
- The study found that CB1 receptors are present in the central nervous system and gonads of two teleost fish, indicating a high similarity in genetic sequences with CB1 genes from other fish species.
- Immunohistochemistry revealed that CB1, sGnRH, and TH molecules are co-distributed in brain areas crucial for regulating reproduction, suggesting that endocannabinoids may play a role in fish reproductive processes.
Article Abstract
Following the discovery of two CB1 genes in the fish Fugu rubripes, investigations on the phylogeny of endocannabinoids have indicated that this system is highly conserved. Our study demonstrated that CB1 receptors are expressed in the CNS and gonads of two teleosts, Carassius auratus and Pelvicachromis pulcher, and they show a high percentage of sequence identity with Fugu rubripes CB(1A) and Danio rerio CB1. By means of immunohistochemistry for CB1, sGnRH, and TH, we found a codistribution of these signaling molecules in the basal telencephalon/preoptic area, which are key centers for gonadotropic regulation. We therefore suggest that endocannabinoids are possibly involved in modulating fish reproduction at both the central and peripheral levels.
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| http://dx.doi.org/10.1196/annals.1327.041 | DOI Listing |
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