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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis.
Sci Rep
January 2025
Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061-0910, USA.
Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. Whereas previous research demonstrated improved sepsis survival in Ticam2 mice, the contribution of TICAM2 to long-term exhaustion memory remained unknown.
View Article and Find Full Text PDFA Review of Emerging Evidence and Clinical Applications of Hyperbaric Oxygen Therapy.
J Intensive Care Med
January 2025
Anand Pharmacy College, Anand, Gujarat, India.
Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves administering 100% oxygen at increased atmospheric pressure to enhance oxygen delivery to tissues. Initially developed for decompression sickness, HBOT has since been utilized for a wide range of medical conditions, including severe infections, non-healing wounds, and, more recently, COVID-19. This review explores the historical development of HBOT, its principles, its emerging role in the management of and its outcome as treatment in COVID-19, particularly in mitigating inflammation, hypoxemia, and oxidative stress.
View Article and Find Full Text PDFSleep recovery ameliorates submandibular salivary gland inflammation associated with paradoxical sleep deprivation in male Wistar rats.
J Appl Oral Sci
January 2025
University of Ibadan, College of Medicine, Department of Physiology, Ibadan, Nigeria.
Objective: Submandibular salivary gland inflammation has been suggested as one of the mechanisms underlying impaired salivary secretion associated with sleep deprivation (SD). However, whether the salivary inflammatory response occurs to the same extent in paradoxical sleep deprivation with or without sleep recovery remains unknown. This study evaluated the extent to which inflammation influences salivary impairments associated with paradoxical sleep deprivation with or without sleep recovery.
View Article and Find Full Text PDFEssential oil of Lippia origanoides as an anesthetic for Piaractus mesopotamicus: implications for induction and recovery times, ventilatory frequency and blood responses after biometric management.
Braz J Biol
January 2025
Universidade Federal de Mato Grosso do Sul - UFMS, Programa de Pós-graduação em Ciência Animal, Campo Grande, MS, Brasil.
This study evaluated the use of the essential oil of Lippia origanoides (EOLO) as an anesthetic for juvenile pacu, Piaractus mesopotamicus. Two experiments were performed. In Experiment I, anesthetic induction and recovery times and ventilatory frequency (VF) were determined for fish (n= 48; 29.
View Article and Find Full Text PDFPurpose Of Review: This review summarizes the current literature on primary graft dysfunction highlighting the current definition, reviewing epidemiology, and describing donor, recipient, and perioperative risk factors in the contemporary era.
Recent Findings: PGD, in its most severe form, complicates 8% of heart transplants and portends a 1-year mortality of close to 40%. PGD is multifactorial and heterogeneous with contributions from donor and recipient risk as well as organ recovery and preservation modalities.
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