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[Correction of rate and structure of ventricular rhythm in permanent atrial fibrillation: a novel pathogenetic approach].

Kardiologiia

August 2004

I. M. Sechenov Moscow Medical Academy, ul. Bolshaya Pirogovskaya, 2/6, 119881 Moscow, Russia.

Aim: To analyze action of digoxin and some non-digitalis drugs (beta-blockers, verapamil, amiodarone, d,l-sotalol) and their combinations on electrical activity of atria, frequency and structure of ventricular rhythm in patients with permanent atrial fibrillation.

Material And Methods: One hundred patients with permanent atrial fibrillation and heart rate at rest above 80 bpm were divided into 9 treatment groups. High-resolution orthogonal Frank lead ECG was recorded before and after allocated treatment.

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Data obtained at analysis of tables of screening diagnosis, cardiointervalograms, tilt tests used in examination of 57 children with neurovegetative vasomotor rhinitis point to disorders in the autonomic nervous system (by initial vegetative tone), vegetative reactivity. Parasympathetic prevalence in the initial vegetative tone and cardiointervalograms stems from sympathetic hypoactivity in the majority of the patients. The above vegetative shifts dictate the necessity of vegetotropic medication inclusion into combined therapy of vasomotor rhinitis.

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We studied correlations between psychoemotional and vegetative disorders in ulcer. 60 patients with ulcer varying in severity were examined. The severity was judged by the disease history, endoscopic and x-ray findings.

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The analysis of heart rate in patients with ischemic heart disease revealed its differences in different periods of a day. In severe disease forms, the daily fluctuation range of some cardiointervalogram parameters is higher and their acrophase is shifted to the night and early morning hours.

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