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Diagnostic Performance of Dermoscopy for Distinguishing Early Melanomas and Intermediate Melanocytic Lesions From Low-Grade Dysplastic Nevi.
J Cutan Med Surg
March 2025
Department of Dermatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
Background: Early melanomas, dysplastic melanocytic nevi, and melanocytic tumours of uncertain malignant potential (MELTUMPs) reveal similar clinic and dermoscopic findings leading to underdiagnosis of malign lesions or unnecessary excision of benign ones. High-grade dysplastic nevi and MELTUMPs in the intermediate category should be recognized and completely excised.
Objectives: We evaluated the diagnostic performance of pattern analysis, ABCD rule, colour, architecture, symmetry, and homogeneity algorithm, melanoma-specific structures and asymmetry of dermoscopic features in distinguishing early melanomas, high-grade dysplastic nevi, and MELTUMPs from low-grade dysplastic nevi.
Validation of markerless video-based gait analysis using pose estimation in toddlers with and without neurodevelopmental disorders.
Front Digit Health
February 2025
Department of Medicine, University of California, Los Angeles, CA, United States.
Introduction: The onset of locomotion is a critical motor milestone in early childhood and increases engagement with the environment. Toddlers with neurodevelopmental disabilities often have atypical motor development that impacts later outcomes. Video-based gait analysis using pose estimation offers an alternative to standardized motor assessments which are subjective and difficult to ascertain in some populations, yet very little work has been done to determine its accuracy in young children.
View Article and Find Full Text PDFTrophoblastic tumor in perimenopausal women: A case report and literature review.
Int J Surg Case Rep
March 2025
Department of Gynecology and Obstetrics, CHU Fattoma Bourguiba, University of Monastir, Tunisia.
Background And Importance: Placental site trophoblastic tumor (PSTT) a rare form of gestational trophoblastic disease, originates from intermediate trophoblastic cells and presents with nonspecific symptoms, complicating diagnosis. PSTT primarily affects women of childbearing age, but occurrences in perimenopausal women are exceptionally rare.
Case Presentation: We report a case of a 54-year-old perimenopausal woman presenting with a two-month history of abnormal uterine bleeding.
Delayed slipped capital femoral epiphysis with hypothyroidism in children: A case report.
Medicine (Baltimore)
March 2025
Department of Orthopedics and Traumatology, The Affiliated Hospital of Yunnan University, Kunming, Yunnan Province, China.
Rationale: Slipped capital femoral epiphysis (SCFE) is a common adolescent hip disorder, but its association with hypothyroidism remains rare and poorly understood. This case highlights the importance of considering endocrine disorders, such as hypothyroidism, as potential risk factors in atypical SCFE presentations, particularly when trauma or other common etiologies are absent.
Patient Concerns: A 14-year-old boy presented with progressive, nontraumatic left hip pain that worsened over 6 weeks, eventually leading to complete immobility.
The atypical KRAS mutation directs TGF-β response towards partial epithelial-to-mesenchymal transition in patient-derived colorectal cancer tumoroids.
Mol Oncol
March 2025
Department of Pathology, Medical University of Vienna, Austria.
Transforming growth factor beta (TGF-β) exhibits complex and context-dependent cellular responses. While it mostly induces tumor-suppressive effects in early stages of tumorigenesis, tumor-promoting properties are evident in advanced disease. This TGF-β duality is still not fully understood, and whether TGF-β supports invasion and metastasis by influencing cancer cells directly, or rather through the stromal tumor compartment, remains a matter of debate.
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