AI Article Synopsis
- A polymorphism (I405V) in the CETP gene was linked to healthy aging in Ashkenazi Jews.
- Researchers tested this genetic effect in Italian centenarians but found no confirmation of the same association.
- The findings imply that factors beyond the I405V variation, including gene-environment interactions, play a role in longevity.
Article Abstract
A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity.
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| http://dx.doi.org/10.1016/j.mad.2005.01.009 | DOI Listing |
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