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Investigation of the Effect of the Shape of Cutting Knives Limiting Burr in High-Strength Multiphase Steel Sheets.
Materials (Basel)
January 2025
Dar Stal Dariusz Zaława, ul. Przemysłowa 7, 42-300 Myszków, Poland.
In this study, numerical modeling and experimental tests of the sheet metal cutting process were carried out in order to determine the shape of the cutting knives for a roller shear, ensuring the minimization of burr on the cut edge. A rolling mill was used for the tests, enabling the replication of the cutting process in a roller shear (demonstrating the possibility of using cutting rollers). The cutting edges of the sheets were examined using light microscopy and then compared with the results of numerical simulations to determine the cutting quality.
View Article and Find Full Text PDFEndoscopic ultrasound-guided biopsy of healthy pig pancreas - Towards the histological diagnosis of chronic pancreatitis.
Rev Esp Enferm Dig
September 2024
Gastroenterology, Hospital Clínico Universitario de Santiago.
Background: diagnosis of early chronic pancreatitis (CP) is a challenge due to the lack of accurate methods. The ability of endoscopic ultrasound (EUS) guided biopsy to obtain pancreatic core tissue samples in patients with minimal changes of CP and its potential use for the histological diagnosis of early CP are unknown. The aim of the study was to evaluate the ability of different EUS-guided biopsy core needles to obtain histological samples of healthy pig pancreas.
View Article and Find Full Text PDFDesign and characterization of hollow microneedles for localized intrascleral drug delivery of ocular formulations.
Methods
December 2024
School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK. Electronic address:
Effective drug delivery to the posterior segment of the eye remains a challenge owing to the limitations of conventional methods such as intravitreal injections, which are associated with significant side effects. This study explored the use of hollow microneedles (HMNs) for localized intrascleral drug delivery as a minimally invasive alternative. Stainless steel HMNs with bevel angles of 30°, 45°, 60°, and 75° were fabricated using wire electron discharge machining.
View Article and Find Full Text PDFBeveled microneedles with channel for transdermal injection and sampling, fabricated with minimal steps and standard MEMS technology.
Lab Chip
January 2025
Sensors and Devices Center, Bruno Kessler Foundation, Via Sommarive 18, 38123 Trento, Italy.
Microneedles hold the potential for enabling shallow skin penetration applications where biomarkers are extracted from the interstitial fluid (ISF) and drugs are injected in a painless and effective manner. To this purpose, needles must have an inner channel. Channeled needles were demonstrated using custom silicon microtechnology, having several needle tip geometries.
View Article and Find Full Text PDFOro-ruminal sampling device and technique for rapid collection of rumen content and improved recovery of solid fractions for microbiome analysis.
JDS Commun
November 2024
Dairy Australia, Melbourne, VIC 3006, Australia.
Rumen fistulation is a widely used procedure that allows for collection of ruminal contents. However, fistulation is an invasive and costly procedure that generally limits the number of animals that can be recruited for experiments, thus encouraging the use of alternative techniques such as the intra-esophageal tube technique. One of the challenges of this technique is the limited ability to collect solid fractions from the rumen content pool, which may affect the microbial community structure in the sample, particularly affecting the recovery and characterization of solid adherent bacteria.
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