Exposure models are needed for comparison of scenarios resulting from alternative policy options. The reliability of models used for such purposes should be quantified by comparing model outputs in a real situation with the corresponding observed exposures. Measurement errors affect the observations, but if the distribution of these errors for single observations is known, the bias caused for the population statistics can be corrected. The current paper does this and calculates model errors for a probabilistic simulation of 48-hr fine particulate matter (PM2.5) exposures. Direct and nested microenvironment-based models are compared. The direct model requires knowledge on the distribution of the indoor concentrations, whereas the nested model calculates indoor concentrations from ambient levels, using infiltration factors and indoor sources. The model error in the mean exposure level was <0.5 microg m(-3) for both models. Relative errors in the estimated population mean were +1% and -5% for the direct and nested models, respectively. Relative errors in the estimated SD were -9% and -23%, respectively. The magnitude of these errors and the errors calculated for population percentiles indicate that the model errors would not drive general conclusions derived from these models, supporting the use of the models as a tool for evaluation of potential exposure reductions in alternative policy scenarios.
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http://dx.doi.org/10.1080/10473289.2005.10464634 | DOI Listing |
Br J Hosp Med (Lond)
January 2025
Speech and Language Rehabilitation Department, Beijing Rehabilitation Hospital Affiliated with Capital Medical University, Beijing, China.
The background for establishing and verifying a dehydration prediction model for elderly patients with post-stroke dysphagia (PSD) based on General Utility for Latent Process (GULP) is as follows: For elderly patients with PSD, GULP technology is utilized to build a dehydration prediction model. This aims to improve the accuracy of dehydration risk assessment and provide clinical intervention, thereby offering a scientific basis and enhancing patient prognosis. This research highlights the innovative application of GULP technology in constructing complex medical prediction models and addresses the special health needs of elderly stroke patients.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Mathematical and Physical Sciences, Catholic University of Temuco, Temuco 4813302, Chile.
: A previous study investigated the in vitro release of methylene blue (MB), a widely used cationic dye in biomedical applications, from nanocellulose/nanoporous silicon (NC/nPSi) composites under conditions simulating body fluids. The results showed that MB release rates varied significantly with the nPSi concentration in the composite, highlighting its potential for controlled drug delivery. To further analyze the relationship between diffusion dynamics and the MB concentration, this study developed a finite element (FE) method to solve Fick's equations governing the drug delivery system.
View Article and Find Full Text PDFPharmaceutics
January 2025
College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.
/: Inhaler devices have been developed for the effective delivery of inhaled medications used in the treatment of pulmonary diseases. However, differing operating procedures across the devices can lead to user errors and reduce treatment efficacy, especially when patients use multiple devices simultaneously. To address this, we developed a novel dry powder inhaler (DPI), combining fluticasone propionate (FP), salmeterol xinafoate (SX), and tiotropium bromide (TB) into a single device designed for bioequivalent delivery compared to existing commercial products in an animal model.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, 31009 Pamplona, Spain.
Background/objectives: Colorectal cancer (CRC) holds the third and second position among cancers affecting men and women, respectively. Frequently, the first-line treatment for metastatic CRC consists of the intravenous administration of 5-fluorouracil and leucovorin in combination with oxaliplatin or irinotecan. Physiologically-based pharmacokinetic models (PBPK) aim to mechanistically incorporate body physiology and drug physicochemical attributes, enabling the description of both systemic and organ drug exposure based on the treatment specificities.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
School of Intelligent Science and Engineering, Hubei Minzu University, Enshi 445000, China.
Rapid heating cycle molding technology has recently emerged as a novel injection molding technique, with the uniformity of temperature distribution on the mold cavity surface being a critical factor influencing product quality. A numerical simulation method is employed to investigate the rapid heating process of molds and optimize heating power, with the positions of heating rods as variables. The temperature uniformity coefficient is an indicator used to assess the uniformity of temperature distribution within a system or process, while the thermal response rate plays a crucial role in evaluating the heating efficiency of a heating system.
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