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The intersection of endocrine signaling and neuroimmune communication regulates muscle inflammation-induced nociception in neonatal mice.
Brain Behav Immun
December 2024
Department of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Pediatric Pain Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, United States. Electronic address:
Neonatal pain is a significant clinical issue but the mechanisms by which pain is produced early in life are poorly understood. Our recent work has linked the transcription factor serum response factor downstream of local growth hormone (GH) signaling to incision-related hypersensitivity in neonates. However, it remains unclear if similar mechanisms contribute to inflammatory pain in neonates.
View Article and Find Full Text PDFPeripheral injury responses essential for muscle repair and nociception require complex interactions of target tissues, immune cells and primary sensory neurons. Nociceptors and myofibers both react robustly to signals generated from circulating immune cells, which promote repair, growth, and regeneration of muscle while simultaneously modulating peripheral sensitization. Here, we found that macrophages form a synaptic-like contact with myofibers to hasten repair after acute incision injury and to facilitate regeneration after major muscle damage.
View Article and Find Full Text PDFDesign and validation of a preclinical model for oral commissure and lower eyelid thermal injury.
Burns
October 2024
Department of Otolaryngology - Head and Neck Surgery, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA; United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA; Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati, Cincinnati, OH, USA.
Article Synopsis
- Oral commissure stenosis and lower eyelid ectropion from burns are difficult to treat due to a lack of preclinical models; this study describes a method for inducing controlled burns in swine to aid future research.
- The experiment involved inducing burns of various durations (10 to 30 seconds) on swine and observing changes over time using techniques like laser speckle imaging for assessing tissue health and healing.
- Results indicated that longer burn times led to more severe tissue damage and inflammation, but no significant functional impairments were noted, suggesting the need for further exploration of treatments with this new burn model.
A Randomized Controlled Trial of 2% Chlorhexidine Gluconate Skin Preparation Cloths for the Prevention of Surgical Site Infections in Adults Undergoing Spine Surgeries: Residual Reduction in Skin Bacterial Load for 4 Days.
HCA Healthc J Med
October 2024
Vanderbilt University Medical Center, Nashville, TN.
Background: Surgical site infections (SSI) result in increased morbidity and mortality, prolonged recovery, longer hospital length of stay for medication or possible additional surgeries, and escalated health care costs. The purpose of this randomized controlled trial was to compare SSI rates and overall skin flora burden between those using chlorhexidine (CHG) cloths versus soap and water preoperatively in the adult spine surgery population.
Methods: Subjects were randomized preoperatively to use 2% CHG cloths versus soap and water the night before and morning of surgery prior to the operation.
Article Synopsis
- The study aimed to describe a new prenatal technique for myelomeningocele (MMC) repair using a minimally invasive method with a decellularized human umbilical cord graft for covering the spinal defect.
- A cohort of 57 patients from an ongoing study showed positive postnatal outcomes, with most patients achieving independent or therapeutic ambulation and a low incidence of serious complications like CSF leaks.
- Findings include a significant rate of complete reversal of hindbrain herniation at birth and a manageable percentage of spinal inclusion cysts that required minimal surgical intervention.
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