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Optimizing demand response and load balancing in smart EV charging networks using AI integrated blockchain framework.
Sci Rep
December 2024
Department of Theoretical Electrical Engineering and Diagnostics of Electrical Equipment, Institute of Electrodynamics, National Academy of Sciences of Ukraine, Beresteyskiy, 56, Kyiv-57, 03680, Kyiv, Ukraine.
The integration of Electric Vehicles (EVs) into power grids introduces several critical challenges, such as limited scalability, inefficiencies in real-time demand management, and significant data privacy and security vulnerabilities within centralized architectures. Furthermore, the increasing demand for decentralized systems necessitates robust solutions to handle the growing volume of EVs while ensuring grid stability and optimizing energy utilization. To address these challenges, this paper presents the Demand Response and Load Balancing using Artificial intelligence (DR-LB-AI) framework.
View Article and Find Full Text PDFD-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer.
Sci Rep
December 2024
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Esophageal cancer is a highly aggressive disease, and acquired resistance to chemotherapy remains a significant hurdle in its treatment. mtDNA, crucial for cellular energy production, is prone to mutations at a higher rate than nuclear DNA. These mutations can accumulate and disrupt cellular function; however, mtDNA mutations induced by chemotherapy in esophageal cancer remain unexplored.
View Article and Find Full Text PDFPlastome characterization and its phylogenetic implications on Lithocarpus (Fagaceae).
BMC Plant Biol
December 2024
Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Institute of Biodiversity, School of Ecology and Environmental Science, Yunnan University, Kunming, 650500, China.
Background: The genus Lithocarpus is a species-rich dominant woody lineage in East Asian evergreen broad-leaved forests. Despite its ecological and economic significance, the plastome structure and evolutionary history of the genus remain poorly understood. In this study, we comprehensively analyzed the 34 plastomes representing 33 Lithocarpus species.
View Article and Find Full Text PDFLaser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons.
J Biol Chem
December 2024
Laboratory of Reproductive Neurobiology, HUN-REN Institute of Experimental Medicine, Budapest, 1083 Hungary. Electronic address:
We developed a versatile 'IHC/LCM-Seq' method for spatial transcriptomics of immunohistochemically detected neurons collected with laser-capture microdissection (LCM). IHC/LCM-Seq uses aluminon and polyvinyl sulfonic acid for inventive RNA-preserving strategies to maintain RNA integrity in free-floating sections of 4% formaldehyde-fixed brains. To validate IHC/LCM-Seq, we first immunostained and harvested striatal cholinergic interneurons with LCM.
View Article and Find Full Text PDFAnalysis of mechanisms of the rabies virus P protein-nucleocapsid interaction using engineered N-protein peptides and potential applications in antivirals design.
Antiviral Res
December 2024
Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:
The Phosphoprotein (P protein) of the rabies virus has multiple roles in virus replication. A critical function is to act as a cofactor in genome replication and mRNA production through binding via its N-terminal region to the L protein, the essential enzyme for mRNA and genome synthesis/processing, and via its C-terminal domain (P) to the N protein and viral RNA (N-RNA) ribonucleoprotein complex. The binding site of the P on the N protein is a disordered loop that is expected to be phosphorylated at Ser389.
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