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Close cooperation between Semi1 and Semi2 proteins is essential for pronuclear positioning in .
Mol Biol Cell
January 2025
Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo 156-8550, Japan.
During sexual reproduction in the ciliate , meiosis occurs in the germline micronucleus, resulting in the formation of four haploid micronuclei. Of these, only one is selected to evade autophagy, and subsequently migrates to the membrane junction with the partner cell for reciprocal pronuclear exchange. We previously demonstrated that the transmembrane protein Semi1 is essential for this nuclear migration.
View Article and Find Full Text PDFThe 'Janus A' gene encodes a polo-kinase whose loss creates a dorsal/ventral intracellular homeosis in the ciliate, .
bioRxiv
December 2024
Department of Cellular Biology, University of Georgia, Athens, GA.
Genetic studies on the protist, provide a glimpse into the unexpectedly rich world of intracellular patterning that unfolds within the ciliate cell cortex. Ciliate pattern studies provide a useful counterpoint to animal models of pattern formation in that the unicellular model draws attention away from fields of cells (or nuclei) as the principal players in the metazoan pattern paradigm, focusing instead on fields of ciliated basal bodies serving as sources of positional information. In this study, we identify , a Polo kinase of , that serves as an important factor driving global, circumferential pattern.
View Article and Find Full Text PDFInferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for .
bioRxiv
December 2024
Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA.
Although an established model organism, remains comparatively inaccessible to high throughput screens, and alternative bioinformatic approaches still rely on unconnected datasets and outdated algorithms. Here, we report a new approach to consolidating RNA-seq and microarray data based on a systematic exploration of parameters and computational controls, enabling us to infer functional gene associations from their co-expression patterns. To illustrate the power of this approach, we took advantage of new data regarding a previously studied pathway, the biogenesis of a secretory organelle called the mucocyst.
View Article and Find Full Text PDFStructure of the ciliary tip central pair reveals the unique role of the microtubule-seam binding protein SPEF1.
bioRxiv
December 2024
Department of Anatomy and Cell Biology, McGill University, Montreal, Québec, Canada.
Motile cilia are unique organelles with the ability to autonomously move. Force generated by beating cilia propels cells and moves fluids. The ciliary skeleton is made of peripheral doublet microtubules and a central pair (CP) with a distinct structure at the tip.
View Article and Find Full Text PDFAn amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes.
Dev Cell
December 2024
Department of Molecular Biosciences, University of Texas, Austin, Austin, TX 78712, USA. Electronic address:
Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human diseases. Motile cilia contain a myriad of different proteins that assemble into an array of distinct machines, and understanding the interactions and functional hierarchies among them presents an important challenge. Here, we defined the protein interactome of motile axonemes using cross-linking mass spectrometry in Tetrahymena thermophila.
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