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Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host-Pathogen Interaction.
Cells
December 2024
Molecular and Cellular Microbiology Laboratory, Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on cell surfaces that impact cell signaling.
View Article and Find Full Text PDFinduced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis.
Elife
December 2024
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Sirtuins are the major players in host immunometabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to salmonellosis is largely unknown. Here, our investigation focussed on the role of two important sirtuins, SIRT1 and SIRT3, shedding light on their impact on intracellular 's metabolic switch and pathogenesis establishment.
View Article and Find Full Text PDFMulti-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation.
Cell Rep
November 2024
Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center (LUMC), 2333 ZC Leiden, the Netherlands. Electronic address:
Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonella induces cell transformation, we performed multi-omics and phenotypic analyses of Salmonella clinical strains isolated from patients later diagnosed with colon cancer (case strains) and control strains from patients without cancer. We show that high transformation efficiency is a frequent intrinsic feature of clinical (case and control) salmonellae, yet case strains showed higher transformation efficiency than control strains.
View Article and Find Full Text PDFSchistosomiasis-Microbiota Interactions: A Systematic Review and Meta-Analysis.
Pathogens
October 2024
Biomedical and Clinical Research Centre, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Introduction: Schistosomiasis, a tropical disease affecting humans and animals, affected 251.4 million people in 2021. , , , and are primary human schistosomes, causing tissue damage, granulomas, ulceration, hemorrhage, and opportunistic pathogen entry.
View Article and Find Full Text PDF5-year vaccine protection following a single dose of Vi-tetanus toxoid conjugate vaccine in Bangladeshi children (TyVOID): a cluster randomised trial.
Lancet
October 2024
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address:
Article Synopsis
- - The study aimed to understand how long the protection from the typhoid conjugate vaccine (TCV) lasts by extending research from the TyVAC trial in Bangladesh to 5 years post-vaccination.
- - It found that children who received the TCV between 2018-2019 had a significantly higher risk of contracting typhoid compared to those vaccinated more recently, indicating that vaccine effectiveness declines over time.
- - The research showed an estimated vaccine effectiveness of only 50% in the 3-5 year period after vaccination, highlighting the need for further studies on booster doses to maintain immunity.
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