AI Article Synopsis
- Recent studies indicate that vascular progenitor cells play a key role in arteriosclerosis-related conditions like transplant arteriosclerosis and vein graft atherosclerosis.
- Research has identified a significant presence of these progenitor cells in the arterial wall's adventitia, which can transform into smooth muscle cells both in lab settings and within living organisms.
- These progenitor cells can migrate into the intima layer of the artery, contributing to the formation of atherosclerotic lesions, suggesting their potential use in treatments involving cell therapy, genetics, and tissue engineering for vascular diseases.
Article Abstract
Accumulating evidence indicates the involvement of vascular progenitor cells in the development of arteriosclerosis, including transplant arteriosclerosis, angioplasty-induced restenosis, vein graft atherosclerosis, and spontaneous atherosclerosis. Recently, it was found that the adventitia of the arterial wall contains a large number of progenitor cells, which can differentiate into smooth muscle cells in vitro and in vivo. These progenitor cells were able to migrate from the adventitia into the intima, where they accumulate to contribute to atherosclerotic lesions of vein grafts in apoE-deficient mice. Thus, these cells may be a source of smooth muscle cells and might have implications for cellular, genetic, and tissue engineering approaches to vascular disease.
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| http://dx.doi.org/10.1016/j.tcm.2005.02.003 | DOI Listing |
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