AI Article Synopsis
- The study investigated elevated levels of cardiac troponin I (cTnI) in patients infected with Legionella pneumophila, suggesting a potential link to the immune response.
- A significant 46.7% of patients showed increased cTnI levels using the RF421A reagent, indicating a strong correlation with positive serology for legionellosis.
- The introduction of a revised cTnI reagent (RF421C) resulted in a dramatic drop in positive rates to 3.3%, suggesting that it reduced interference from antibodies related to the infection.
Article Abstract
We found an unusually high positive rate for cTnI in patients recently infected with Legionella pneumophila. The aim of this study was to examine the possible origin of increased cTnI levels and to test if it could be associated with the immune response to legionellosis. The cTnI was above the cut point in 46.7% of patients infected with legionellosis when measured with reagent lot number RF421A. A strong correlation between high cTnI measurements and positive serologic values for legionellosis was found. With a revised formulation of cTnI reagent, lot number RF421C, the positive rate decreased by over 10-fold to 3.3%. We conclude that the revised lot of cTnI reagent minimized interference by heterophilic antibodies produced in response to legionellosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinbiochem.2005.01.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sprinkler irrigation of urban sport fields as a potential source of .
Arch Environ Occup Health
January 2025
Environmental Quality and Intervention Department, Agència de Salut Pública de Barcelona, Barcelona, Spain.
Following a legionnaire's disease outbreak in Barcelona in 2022, sport fields' sprinklers were identified as potential sources of Legionella infection. The Agency of Public Health of Barcelona inspected all 40 urban municipal sports fields in the city. was found in 55% of them, including in 11 samples.
View Article and Find Full Text PDFCorrelation Between Inflammatory Markers and Pathogenic Bacteria in Children's Winter Respiratory Infections in Xinjiang.
Int J Gen Med
January 2025
Department of Respiratory and Critical Care Medical Department Infectious Diseases Ward, The Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
Background: This study examines the distribution characteristics of pathogenic bacteria in respiratory infections and their relationship with inflammatory markers to guide clinical drug use.
Methods: We selected 120 patients with lower respiratory tract infection in the electronic medical record system of Xinjiang Provincial People's Hospital from March 2019 to March 2023 for a case-control study. Using Indirect Immunofluorescence Antibody test(IFA), blood routine, C-reactive Protein (CRP), and High-sensitivity C-reactive Protein(hsCRP), we detected nine respiratory pathogens (Respiratory syncytial virus; Influenza A virus; Influenza B virus; Parainfluenza virus; Adenovirus; Mycoplasma pneumoniae; Chlamydia pneumoniae; Legionella pneumophila type 1; Rickettsia Q) in all patients and analyzed their distribution and correlation.
The Passage of Chaperonins to Extracellular Locations in Requires a Functional Dot/Icm System.
Biomolecules
January 2025
Department of Microbiology-Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada.
HtpB, the chaperonin of the bacterial pathogen , is found in extracellular locations, even the cytoplasm of host cells. Although chaperonins have an essential cytoplasmic function in protein folding, HtpB exits the cytoplasm to perform extracellular virulence-related functions that support 's lifestyle. The mechanism by which HtpB reaches extracellular locations is not currently understood.
View Article and Find Full Text PDFLD-transpeptidase-mediated cell envelope remodeling enables developmental transitions and survival in and .
J Bacteriol
January 2025
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York, USA.
and are two phylogenetically related bacterial pathogens that exhibit extreme intrinsic resistance when they enter into a dormancy-like state. This enables both pathogens to survive extended periods in growth-limited environments. Survival is dependent upon their ability to undergo developmental transitions into two phenotypically distinct variants, one specialized for intracellular replication and another for prolonged survival in the environment and host.
View Article and Find Full Text PDFOccurrence of macrolides resistance in Legionella pneumophila ST188: results of the Belgian epidemiology and resistome investigation of clinical isolates.
Int J Infect Dis
January 2025
National reference centre for Legionella pneumophila, Department of Microbiology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium.
Introduction: The incidence of Legionnaires' disease (LD) steadily increases worldwide. Although Legionella pneumophila is known as pathogenic, systematic investigations into antibiotic resistance are scarce, and reports of resistance in isolates are recently emerging.
Methods: Clinical cases and metadata reported to the Belgian National Reference Centre between 2011 and 2022 were retrospectively analysed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!